Sulfonamides and Trimethoprim

General Principles

Sulfadiazine, sulfamethoxazole, and trimethoprim slowly kill bacteria by inhibiting folic acid metabolism. This class of antibiotics is most commonly used for uncomplicated UTIs, sinusitis, and otitis media. Some sulfonamide-containing agents also have unique roles in the treatment of P. jirovecii, Nocardia, Toxoplasma, and Stenotrophomonas infections.

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