Sulfonamides and Trimethoprim

Sulfonamides and Trimethoprim is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Sulfadiazine, sulfamethoxazole, and trimethoprim slowly kill bacteria by inhibiting folic acid metabolism. This class of antibiotics is most commonly used for uncomplicated UTIs, sinusitis, and otitis media. Some sulfonamide-containing agents also have unique roles in the treatment of P. jirovecii, Nocardia, Toxoplasma, and Stenotrophomonas infections.

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