Breast Cancer

Breast Cancer is a topic covered in the Washington Manual of Medical Therapeutics.

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Epidemiology and Etiology

Breast cancer is the most common cancer in women in developed countries and the second leading cause of cancer death.1 Less than 1% of cases are reported in men. The lifetime risk of breast cancer among women in the US is 12%. BRCA1 and BRCA2 mutations are associated with significantly increased lifetime risk of breast cancer. However, less than 10% of all breast cancers are attributable to mutations involving susceptibility genes.2 Other risk factors include alcohol consumption, early menarche, late menopause, nulliparity, postmenopausal obesity, hormone replacement therapy, delayed first pregnancy, and prior mantle field radiation for Hodgkin lymphoma.

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Epidemiology and Etiology

Breast cancer is the most common cancer in women in developed countries and the second leading cause of cancer death.1 Less than 1% of cases are reported in men. The lifetime risk of breast cancer among women in the US is 12%. BRCA1 and BRCA2 mutations are associated with significantly increased lifetime risk of breast cancer. However, less than 10% of all breast cancers are attributable to mutations involving susceptibility genes.2 Other risk factors include alcohol consumption, early menarche, late menopause, nulliparity, postmenopausal obesity, hormone replacement therapy, delayed first pregnancy, and prior mantle field radiation for Hodgkin lymphoma.

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