Microangiopathic Hemolytic Anemia

Microangiopathic Hemolytic Anemia is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Microangiopathic hemolytic anemia (MAHA) is a syndrome of traumatic intravascular hemolysis causing fragmentation of the RBCs that are seen on peripheral blood smear (schistocytes). It is not a specific diagnosis but suggests a limited differential diagnosis.

Etiology

Possible causes of MAHA include mechanical heart valve, malignant hypertension, vasculitis, adenocarcinoma, preeclampsia/eclampsia, disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), and hemolytic-uremic syndrome (HUS)/atypical HUS (see Chapter 20, Disorders of Hemostasis and Thrombosis, for a discussion of DIC, TTP, and HUS/atypical HUS).

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General Principles

Definition

Microangiopathic hemolytic anemia (MAHA) is a syndrome of traumatic intravascular hemolysis causing fragmentation of the RBCs that are seen on peripheral blood smear (schistocytes). It is not a specific diagnosis but suggests a limited differential diagnosis.

Etiology

Possible causes of MAHA include mechanical heart valve, malignant hypertension, vasculitis, adenocarcinoma, preeclampsia/eclampsia, disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), and hemolytic-uremic syndrome (HUS)/atypical HUS (see Chapter 20, Disorders of Hemostasis and Thrombosis, for a discussion of DIC, TTP, and HUS/atypical HUS).

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