Polymyositis and Dermatomyositis
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- Polymyositis (PM) is an inflammatory myopathy that presents as weakness and occasionally tenderness of the proximal musculature.
- Dermatomyositis (DM) is an inflammatory myopathy associated with proximal muscle weakness and a characteristic skin rash. Gottron papules and a heliotrope rash are hallmark features of DM, but other skin manifestations may be seen.
- PM and DM can occur alone or in association with a variety of neoplasms. Patients with rheumatic diseases such as SLE or RA can also have myositis.
- Antisynthetase syndrome is myositis spectrum disease that is associated with several antisynthetase antibodies including anti-Jo1, anti-PL7, anti-PL12, anti-OJ, anti-EJ, anti-KS, anti-Ha, and anti-Zo. This syndrome often presents acutely with fever, arthritis, characteristic rash on the hands called as mechanics hands, and interstitial lung disease.