Chronic Allograft Dysfunction

General Principles

  • Chronic allograft dysfunction accounts for the vast majority of late graft losses and is the major obstacle to long-term graft survival.
  • Chronic allograft dysfunction (formerly chronic rejection) is a slowly progressive, insidious decline in function of the allograft characterized by gradual vascular and ductal obliteration, parenchymal atrophy, and interstitial fibrosis.

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