Membranous Nephropathy

Membranous Nephropathy is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • MN usually presents with the nephrotic syndrome or heavy proteinuria, whereas renal function is often normal or near normal. Disease progression is variable, with one-third remitting spontaneously, one-third progressing to ESRD, and one-third with an intermediate course.
  • Secondary forms of MN are associated with systemic lupus erythematosus (SLE; class V), viral hepatitis, syphilis, or solid organ malignancies. Medications such as gold and penicillamine can also induce this process.

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General Principles

  • MN usually presents with the nephrotic syndrome or heavy proteinuria, whereas renal function is often normal or near normal. Disease progression is variable, with one-third remitting spontaneously, one-third progressing to ESRD, and one-third with an intermediate course.
  • Secondary forms of MN are associated with systemic lupus erythematosus (SLE; class V), viral hepatitis, syphilis, or solid organ malignancies. Medications such as gold and penicillamine can also induce this process.

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