Hypermagnesemia
Hypermagnesemia is a topic covered in the Washington Manual of Medical Therapeutics.
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General Principles
- A serum magnesium >2.2 mEq/L defines hypermagnesemia.
- Most cases of clinically significant hypermagnesemia are iatrogenic, occurring with large doses of magnesium-containing antacids or laxatives and during treatment of preeclampsia with IV magnesium. Because renal excretion is the only means of lowering serum magnesium levels, the presence of significant renal insufficiency can lead to magnesium toxicity even with therapeutic doses of these antacids and laxatives.
- Mild, insignificant elevations in magnesium can occur in end-stage renal disease patients, theophylline intoxication, DKA, and tumor lysis syndrome.
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General Principles
- A serum magnesium >2.2 mEq/L defines hypermagnesemia.
- Most cases of clinically significant hypermagnesemia are iatrogenic, occurring with large doses of magnesium-containing antacids or laxatives and during treatment of preeclampsia with IV magnesium. Because renal excretion is the only means of lowering serum magnesium levels, the presence of significant renal insufficiency can lead to magnesium toxicity even with therapeutic doses of these antacids and laxatives.
- Mild, insignificant elevations in magnesium can occur in end-stage renal disease patients, theophylline intoxication, DKA, and tumor lysis syndrome.
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Citation
Bhat, Pavat, et al., editors. "Hypermagnesemia." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. The Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602624/all/Hypermagnesemia.
Hypermagnesemia. In: Bhat PP, Dretler AA, Gdowski MM, et al, eds. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602624/all/Hypermagnesemia. Accessed February 8, 2023.
Hypermagnesemia. (2016). In Bhat, P., Dretler, A., Gdowski, M., Ramgopal, R., & Williams, D. (Eds.), Washington Manual of Medical Therapeutics (35th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602624/all/Hypermagnesemia
Hypermagnesemia [Internet]. In: Bhat PP, Dretler AA, Gdowski MM, Ramgopal RR, Williams DD, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2023 February 08]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602624/all/Hypermagnesemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Hypermagnesemia
ID - 602624
ED - Williams,Dominique,
ED - Bhat,Pavat,
ED - Dretler,Alexandra,
ED - Gdowski,Mark,
ED - Ramgopal,Rajeev,
BT - Washington Manual of Medical Therapeutics
UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602624/all/Hypermagnesemia
PB - Wolters Kluwer Health
ET - 35
DB - The Washington Manual
DP - Unbound Medicine
ER -