Cephalosporins is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Cephalosporins exert their bactericidal effect by interfering with cell wall synthesis by the same mechanism as PCNs.
  • These agents are clinically useful because of their broad spectrum of activity and low toxicity profile. All cephalosporins are devoid of clinically significant activity against enterococci when used alone. Within this class, only ceftaroline is active against methicillin-resistant S. aureus (MRSA).

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