Tags

Type your tag names separated by a space and hit enter

Myelodysplastic Syndrome

Myelodysplastic Syndrome is a topic covered in the Washington Manual of Medical Therapeutics.

To view the entire topic, please or purchase a subscription.

The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:

Washington Manual

-- The first section of this topic is shown below --

Epidemiology and Etiology

  • Myelodysplastic syndromes (MDSs) comprise a heterogeneous group of myeoid neoplasms that are broadly characterized by cytopenias associated with a dysmorphic and usually cellular bone marrow and an increased risk of leukemic transformation. The median age at diagnosis is ≥65 years for de novo MDS. Cytopenias in MDS are due to clonal abnormalities of marrow cells affecting one or more cell lines, ultimately leading to reduced hematopoiesis. Therapy-related myeloid neoplasms, including acute myeloid leukemia (AML) and MDS, account for 10%–20% of all myeloid neoplasms.
  • Environmental factors such as exposure to chemicals, radiation, and chemotherapy, as well as genetic syndromes and benign hematologic disorders (such as paroxysmal nocturnal hemoglobinuria), have been associated with an increased risk of MDS.
  • Chromosome abnormalities occur in up to 80% of cases, leading to accumulation of multiple genetic lesions, loss of tumor suppressor genes, and/or activating oncogene mutations.

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

Williams, Dominique, et al., editors. "Myelodysplastic Syndrome." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602649/all/Myelodysplastic_Syndrome.
Myelodysplastic Syndrome. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602649/all/Myelodysplastic_Syndrome. Accessed July 19, 2019.
Myelodysplastic Syndrome. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602649/all/Myelodysplastic_Syndrome
Myelodysplastic Syndrome [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 July 19]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602649/all/Myelodysplastic_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Myelodysplastic Syndrome ID - 602649 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602649/all/Myelodysplastic_Syndrome PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -