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Dalbavancin (1500 mg single dose or 1000 mg IV on day 1 followed by 500 mg IV on day 8 to complete the course of therapy) is a long-acting lipoglycopeptide (terminal half-life of 346 hours) that inhibits cell wall biosynthesis and demonstrates concentration-dependent bactericidal activity. Dalbavancin has activity against many gram-positive aerobic bacteria, including staphylococci (including MRSA) and streptococci, and is FDA approved for acute bacterial skin and skin structure infections.