Clonidine

Clonidine is a topic covered in the Washington Manual of Medical Therapeutics.

To view the entire topic, please or purchase a subscription.

The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:

Washington Manual

-- The first section of this topic is shown below --

General Principles

  • Clonidine is an orally administered agent used in the management of hypertension.
  • Clonidine is an imidazoline drug with centrally acting antihypertensive effects related to α2-agonism, which decreases sympathetic outflow from the CNS.1 Other drugs in this family include oxymetazoline and tetrahydrozoline, nasal decongestants that exhibit similar toxicity when orally administered. In overdose, peripheral effects include an initial release of norepinephrine with a transient increase in BP, followed by hypotension.2

-- To view the remaining sections of this topic, please or purchase a subscription --