Clonidine is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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General Principles

  • Clonidine is an orally administered agent used in the management of hypertension.
  • Clonidine is an imidazoline drug with centrally acting antihypertensive effects related to α2-agonism, which decreases sympathetic outflow from the CNS.1 Other drugs in this family include oxymetazoline and tetrahydrozoline, nasal decongestants that exhibit similar toxicity when orally administered. In overdose, peripheral effects include an initial release of norepinephrine with a transient increase in BP, followed by hypotension.2

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