The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
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- These agents include diuretics, α1-antagonists, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs).
- Diuretics tend to be benign in overdose. Occasionally, they cause dehydration and electrolyte imbalances. Laboratory studies should include a BMP. Management usually only requires gentle fluid hydration.
- α1-Antagonists cause peripheral vasodilation, which usually responds to hydration. Occasionally, they cause enough hypotension to require vasopressors. In these cases, norepinephrine should be administered.
- ACE inhibitors rarely cause significant toxicity, although there are case reports of fatal overdoses. Treatment is supportive. In patients with hypotension, naloxone may be useful.1
- ARBs may cause hypotension in overdose. Treatment is supportive.