Other Antihypertensives

Other Antihypertensives is a topic covered in the Washington Manual of Medical Therapeutics.

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  • These agents include diuretics, α1-antagonists, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs).
  • Diuretics tend to be benign in overdose. Occasionally, they cause dehydration and electrolyte imbalances. Laboratory studies should include a BMP. Management usually only requires gentle fluid hydration.
  • α1-Antagonists cause peripheral vasodilation, which usually responds to hydration. Occasionally, they cause enough hypotension to require vasopressors. In these cases, norepinephrine should be administered.
  • ACE inhibitors rarely cause significant toxicity, although there are case reports of fatal overdoses. Treatment is supportive. In patients with hypotension, naloxone may be useful.1
  • ARBs may cause hypotension in overdose. Treatment is supportive.

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