Oritavancin

Oritavancin is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Oritavancin (1200 mg IV administered once to complete therapy) is a long-acting lipoglycopeptide (terminal half-life, 245 hours) that inhibits cell wall biosynthesis through multiple mechanisms. Oritavancin has activity against many gram-positive aerobic bacteria, including staphylococci (including MRSA) and streptococci, as well as some enterococci (including some strains resistant to vancomycin).

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