Serotonin Syndrome

Serotonin Syndrome is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Serotonin syndrome is a disorder that can be precipitated by the introduction of a serotonergic agent and has been reported to occur even after ingestion of a single pill.1

Pathophysiology

Serotonin syndrome is thought to occur secondary to excess stimulation of 5HT2A receptors.2 This syndrome can result from the coadministration of two or more serotonergic agents including SSRIs, MAOIs, meperidine, amphetamines, cocaine, TCAs, and various other drugs.

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