Lamotrigine

Lamotrigine is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Lamotrigine, an anticonvulsant, is widely prescribed as a mood stabilizer as well as for the treatment of partial complex seizures.

Pathophysiology

Lamotrigine exerts its therapeutic effects by blocking presynaptic and postsynaptic sodium channels. In overdose, excess sodium channel blockade may result in widening of the QRS on the ECG and conduction blocks. Idiopathic cases of dermatologic pathology including AHS, Steven–Johnson syndrome, and toxic epidermal necrolysis have been reported with the therapeutic administration of lamotrigine.

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