Methanol

Methanol is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Methanol is used in gasoline, antifreeze, deicers, windshield washer fluid, paint and varnish removers, fuel, photocopy fluid, and embalming fluids. It can be found in “moonshine” liquor and is used as a denaturant for ethanol.

Etiology

Ingestions are mostly intentional, occurring as suicide attempts.

Pathophysiology

Methanol is oxidized to formic acid, which is responsible for the anion gap metabolic acidosis in methanol poisoning.1

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General Principles

Definition

Methanol is used in gasoline, antifreeze, deicers, windshield washer fluid, paint and varnish removers, fuel, photocopy fluid, and embalming fluids. It can be found in “moonshine” liquor and is used as a denaturant for ethanol.

Etiology

Ingestions are mostly intentional, occurring as suicide attempts.

Pathophysiology

Methanol is oxidized to formic acid, which is responsible for the anion gap metabolic acidosis in methanol poisoning.1

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