Erlichiosis and Anaplasmosis

Erlichiosis and Anaplasmosis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Ehrlichiosis and anaplasmosis are systemic tick-borne infections caused by obligate intracellular bacteria of the Anaplasmataceae family. Two similar syndromes are recognized:

  • Human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and transmitted by the lone star tick, is endemic to the southern and south central United States.
  • Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum, is found in the same regions as Lyme disease and shares the same tick vector (Ixodes spp.).

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