Nonsteroidal Antiinflammatory Drugs

Nonsteroidal Antiinflammatory Drugs is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • NSAIDs are widely prescribed as analgesics for the management of inflammatory diseases. There are many different classes available; however, the discussion in the following text relates to over-the-counter preparations available in the United States and includes ibuprofen, ketoprofen, and naproxen as well as the selective cyclooxygenase (COX)-2 inhibitors.
  • NSAIDs exert their therapeutic effects by inhibiting COX and thereby preventing the formation of prostaglandins. This mechanism accounts for both their therapeutic and toxic side effects, which include ulceration of the GI mucosa and renal dysfunction. In the vast majority of cases, overdose is benign.

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General Principles

  • NSAIDs are widely prescribed as analgesics for the management of inflammatory diseases. There are many different classes available; however, the discussion in the following text relates to over-the-counter preparations available in the United States and includes ibuprofen, ketoprofen, and naproxen as well as the selective cyclooxygenase (COX)-2 inhibitors.
  • NSAIDs exert their therapeutic effects by inhibiting COX and thereby preventing the formation of prostaglandins. This mechanism accounts for both their therapeutic and toxic side effects, which include ulceration of the GI mucosa and renal dysfunction. In the vast majority of cases, overdose is benign.

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