• Dengue virus is transmitted by Aedes mosquitoes. It is endemic in Asia, the Pacific, Africa, South and Central America, and the Caribbean.
  • Most cases in the US involve travelers, but local outbreaks have occurred in Texas and Florida (Key West). There are five different dengue virus serotypes (DENV 1–5); infection with one does not protect against others. Higher immune response can happen on subsequent exposures to DENV serotypes.

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