Lyme Disease

General Principles

  • Lyme borreliosis is a systemic illness of variable severity caused by the spirochete Borrelia burgdorferi and is the most common vector-borne disease in the US. It is seen in endemic regions, including the northeastern US coast, the upper Midwest, and northern California.
  • Prophylactic doxycycline 200 mg PO (single dose) is recommended within 72 hours of removal of a high-risk tick bite meeting the following criteria: (1) an Ixodes spp. tick was identified, (2) the bite occurred in a highly endemic region, and (3) the tick was attached for ≥36 hours.1

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