Hepatitis C Virus

Hepatitis C Virus is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • HCV is an RNA virus in the flavivirus family. There are six genotypes with multiple subtypes. Genotype 1 accounts for about 75% and genotypes 2 and 3 account for about 20% of HCV infections in the United States.
  • HCV is the most common chronic bloodborne infection and is a global health problem, with approximately 180 million carriers worldwide.
  • The most frequent mode of transmission is parenteral. Less common modes of transmission include high-risk sexual practices and perinatal transmission. Transmission by transfusion of blood products (and their derivatives) and organ transplantation has been reduced to near zero in developed countries because of screening.

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