Viral Hemorrhagic Fevers: Ebola Virus Disease

Viral Hemorrhagic Fevers: Ebola Virus Disease is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • This syndrome is caused by many different RNA viruses, including filoviruses (Ebola and Marburg), flaviviruses (dengue, yellow fever), bunyaviruses (Hantaviruses, Congo–Crimean hemorrhagic fever [CCHF], Rift Valley fever [RVF]), and arenaviruses (South American hemorrhagic fevers, Lassa fever) (Table 14-12).
  • The 2014-16 West African Ebola Virus Disease (EVD) epidemic and subsequent outbreaks in Central Africa demonstrate that sustained human-to-human transmission of EVD is possible in vulnerable populations.1
  • Case-fatality rates are variable but can be as high as 90% for EVD in resource-limited settings.

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