Myeloproliferative Neoplasms

Myeloproliferative Neoplasms is a topic covered in the Washington Manual of Medical Therapeutics.

To view the entire topic, please or .

The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:

-- The first section of this topic is shown below --

General Principles

MPNs are a group of disorders characterized by clonal expansion of a hematopoietic stem cell resulting in overproduction of mature, largely functional cells. The 2016 World Health Organization (WHO) designated seven conditions as MPNs, including polycythemia vera (PV), essential thrombocythemia (ET) (discussed in Chapter 22, Cancer), CML (discussed in Chapter 22, Cancer), primary myelofibrosis (PMF), chronic neutrophilic leukemia, chronic eosinophilic leukemia, and MPN unclassifiable.1 The most common MPNs include PV, ET, CML, and PMF. This section will focus on PV and PMF.

-- To view the remaining sections of this topic, please or --

General Principles

MPNs are a group of disorders characterized by clonal expansion of a hematopoietic stem cell resulting in overproduction of mature, largely functional cells. The 2016 World Health Organization (WHO) designated seven conditions as MPNs, including polycythemia vera (PV), essential thrombocythemia (ET) (discussed in Chapter 22, Cancer), CML (discussed in Chapter 22, Cancer), primary myelofibrosis (PMF), chronic neutrophilic leukemia, chronic eosinophilic leukemia, and MPN unclassifiable.1 The most common MPNs include PV, ET, CML, and PMF. This section will focus on PV and PMF.

There's more to see -- the rest of this entry is available only to subscribers.