Myeloproliferative Neoplasms

General Principles

MPNs are a group of hematologic malignancies characterized by clonal expansion of a hematopoietic stem cell resulting in overproduction of mature, largely functional cells. The 2016 World Health Organization (WHO) designated seven conditions as MPNs, including polycythemia vera (PV), essential thrombocythemia (ET) (discussed in Chapter 22, Cancer), CML (discussed in Chapter 22, Cancer), primary myelofibrosis (PMF), chronic neutrophilic leukemia, chronic eosinophilic leukemia, and MPN unclassifiable.1 The most common MPNs include PV, ET, CML, and PMF. This section will focus on PV and PMF.

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