IgA Nephropathy/Henoch–Schönlein Purpura

IgA Nephropathy/Henoch–Schönlein Purpura is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • IgA nephropathy is typically idiopathic, characterized by a nephritic picture with microscopic (and less commonly macroscopic) hematuria and mild non-nephrotic range proteinuria.
  • Presentation is most commonly in the second or third decade of life, generally following a slowly progressive course. Some patients may exhibit a crescentic form with a rapid decline in renal function resulting in ESRD.
  • Henoch–Schönlein purpura is a related disorder that may represent a systemic form of the same disease, with vasculitic involvement of the skin (palpable purpura of the lower trunk and extremities), gastrointestinal tract, and joints.

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General Principles

  • IgA nephropathy is typically idiopathic, characterized by a nephritic picture with microscopic (and less commonly macroscopic) hematuria and mild non-nephrotic range proteinuria.
  • Presentation is most commonly in the second or third decade of life, generally following a slowly progressive course. Some patients may exhibit a crescentic form with a rapid decline in renal function resulting in ESRD.
  • Henoch–Schönlein purpura is a related disorder that may represent a systemic form of the same disease, with vasculitic involvement of the skin (palpable purpura of the lower trunk and extremities), gastrointestinal tract, and joints.

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