Complicated Skin and Soft-Tissue Infections

General Principles

Deep soft-tissue infections, surgical and traumatic wound infections, large abscesses, complicated cellulitis, and infected ulcers and burns fall under this classification.


Cultures of abscesses and surgical debridement specimens should be obtained to guide antibiotic therapy.


Patients should be hospitalized to receive IV antibiotics (including MRSA coverage) and undergo surgical intervention as necessary. Vancomycin 15–20 mg/kg IV q12h, linezolid 600 mg PO/IV q12h, daptomycin 4 mg/kg IV qday, clindamycin 900 mg IV q8h, and ceftaroline 600 mg IV q12h are all acceptable antibiotic options.1


  1. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59(2):147-159.  [PMID:24947530]


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