Amphotericin B Formulations

Amphotericin B Formulations is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Amphotericin B is fungicidal by interacting with ergosterol and disrupting the fungal cell membrane. Reformulation of this agent in various lipid vehicles has decreased some of its adverse side effects. Amphotericin B formulations are not effective for Pseudallescheria boydii, Candida lusitaniae, or Aspergillus terreus infections.

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General Principles

Amphotericin B is fungicidal by interacting with ergosterol and disrupting the fungal cell membrane. Reformulation of this agent in various lipid vehicles has decreased some of its adverse side effects. Amphotericin B formulations are not effective for Pseudallescheria boydii, Candida lusitaniae, or Aspergillus terreus infections.

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