Spondyloarthritis

Spondyloarthritis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • The spondyloarthritides (SpAs) are an interrelated group of disorders characterized by one or more of the following features: spondylitis, sacroiliitis, enthesopathy (inflammation at sites of tendon insertion), and asymmetric oligoarthritis. The majority of the patients present before the age of 45. SpAs have an association with HLA-B27. These diseases are classified by their location (peripheral or axial) and by the subtype.
    • Ankylosing spondylitis (AS)
    • Psoriatic arthritis (PsA)
    • Reactive arthritis (ReA)
    • Inflammatory bowel disease (IBD) or enteropathic arthritis
    • Undifferentiated spondyloarthritis (USpA)
  • In clinical practice, SpAs overlap significantly. USpA refers to patients with features of SpA without AS, psoriasis, IBD, or a prodromal infection that could account for ReA. Of the subtypes, AS and PsA are the most prevalent.

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General Principles

  • The spondyloarthritides (SpAs) are an interrelated group of disorders characterized by one or more of the following features: spondylitis, sacroiliitis, enthesopathy (inflammation at sites of tendon insertion), and asymmetric oligoarthritis. The majority of the patients present before the age of 45. SpAs have an association with HLA-B27. These diseases are classified by their location (peripheral or axial) and by the subtype.
    • Ankylosing spondylitis (AS)
    • Psoriatic arthritis (PsA)
    • Reactive arthritis (ReA)
    • Inflammatory bowel disease (IBD) or enteropathic arthritis
    • Undifferentiated spondyloarthritis (USpA)
  • In clinical practice, SpAs overlap significantly. USpA refers to patients with features of SpA without AS, psoriasis, IBD, or a prodromal infection that could account for ReA. Of the subtypes, AS and PsA are the most prevalent.

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