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Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men.

Abstract

Although the association between alcohol intake and gallstone disease has been characterized previously, the relation between alcohol consumption patterns, specific types of alcoholic beverages, and risk for cholelithiasis has not been addressed systematically. These issues were examined prospectively in a cohort of men who were free from symptomatic gallstone disease in 1986 and were followed to 1996. During follow-up, 2.4% of the men reported newly symptomatic gallstones that were diagnosed by ultrasonography or x-ray, or a cholecystectomy. After adjusting for other known or suspected risk factors, an increase in the amount of alcohol consumed was associated with a decreased risk of symptomatic gallstone disease. An increase in frequency of alcohol consumption also was related to decreased risk. Combining the reports of quantity and frequency of alcohol intake, a consumption pattern that reflected frequent intake (5-7 days/week) of any given amount of alcohol was associated with a decreased risk, as compared with nondrinkers. In contrast, infrequent alcohol intake (1-2 days/week) showed no significant association with risk. All alcoholic beverage types were inversely associated with risk of symptomatic gallstone disease, independent of patterns of consumption. These results suggest that frequent, moderate intake of alcohol decreases the risk for symptomatic gallstone disease, in contrast to infrequent or episodic alcohol intake. Recommendations regarding the benefit of moderate quantities of alcohol for gallstone discase should be weighed against the potential health hazards of alcohol consumption.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

    , , , , ,

    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Alcoholic Beverages
    Cholelithiasis
    Cohort Studies
    Comorbidity
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Periodicity
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Temperance

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10371403

    Citation

    Leitzmann, M F., et al. "Prospective Study of Alcohol Consumption Patterns in Relation to Symptomatic Gallstone Disease in Men." Alcoholism, Clinical and Experimental Research, vol. 23, no. 5, 1999, pp. 835-41.
    Leitzmann MF, Giovannucci EL, Stampfer MJ, et al. Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men. Alcohol Clin Exp Res. 1999;23(5):835-41.
    Leitzmann, M. F., Giovannucci, E. L., Stampfer, M. J., Spiegelman, D., Colditz, G. A., Willett, W. C., & Rimm, E. B. (1999). Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men. Alcoholism, Clinical and Experimental Research, 23(5), pp. 835-41.
    Leitzmann MF, et al. Prospective Study of Alcohol Consumption Patterns in Relation to Symptomatic Gallstone Disease in Men. Alcohol Clin Exp Res. 1999;23(5):835-41. PubMed PMID: 10371403.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men. AU - Leitzmann,M F, AU - Giovannucci,E L, AU - Stampfer,M J, AU - Spiegelman,D, AU - Colditz,G A, AU - Willett,W C, AU - Rimm,E B, PY - 1999/6/17/pubmed PY - 1999/6/17/medline PY - 1999/6/17/entrez SP - 835 EP - 41 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 23 IS - 5 N2 - Although the association between alcohol intake and gallstone disease has been characterized previously, the relation between alcohol consumption patterns, specific types of alcoholic beverages, and risk for cholelithiasis has not been addressed systematically. These issues were examined prospectively in a cohort of men who were free from symptomatic gallstone disease in 1986 and were followed to 1996. During follow-up, 2.4% of the men reported newly symptomatic gallstones that were diagnosed by ultrasonography or x-ray, or a cholecystectomy. After adjusting for other known or suspected risk factors, an increase in the amount of alcohol consumed was associated with a decreased risk of symptomatic gallstone disease. An increase in frequency of alcohol consumption also was related to decreased risk. Combining the reports of quantity and frequency of alcohol intake, a consumption pattern that reflected frequent intake (5-7 days/week) of any given amount of alcohol was associated with a decreased risk, as compared with nondrinkers. In contrast, infrequent alcohol intake (1-2 days/week) showed no significant association with risk. All alcoholic beverage types were inversely associated with risk of symptomatic gallstone disease, independent of patterns of consumption. These results suggest that frequent, moderate intake of alcohol decreases the risk for symptomatic gallstone disease, in contrast to infrequent or episodic alcohol intake. Recommendations regarding the benefit of moderate quantities of alcohol for gallstone discase should be weighed against the potential health hazards of alcohol consumption. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/10371403/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1999&volume=23&issue=5&spage=835 DB - PRIME DP - Unbound Medicine ER -