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Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine.

Abstract

We studied hemostatic and inflammatory cardiovascular risk factors (CVRF), and total plasma homocysteine (tHcy) in 26 vegetarians (23 lacto- or ovolactovegetarians and 3 vegans), matched by age, sex and socioeconomic status with omnivorous controls. Vegetarians had significantly lower proportion of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in plasma lipids, significantly shortened bleeding time, and increased blood platelet count and in vitro platelet function (aggregation and secretion). Plasma levels of all coagulation or fibrinolytic factors and natural inhibitors synthesized in the liver were lower in vegetarians than in controls. Whereas for some factors this decrease was statistically significant (fibrinogen, factor VIIc, antithrombin III, protein S, plasminogen) for the remaining (factors VIIIc, Vc, prothrombin, protein C) a trend in the same direction was found. For hemostatic proteins of predominantly extrahepatic origin (von Willebrand factor. tPA, PAI-1) this tendency was not present. No significant differences in inflammatory proteins (C-reactive protein and alpha1-protease inhibitor) were detected in both groups. tHcy was significantly increased in vegetarians, and correlated only with cobalamin levels. The increased platelet function and tHcy found in vegetarians may counteract the known cardiovascular health benefits of vegetarian diet (VD).

Authors+Show Affiliations

,

Department of Hematology-Oncology and Nutrition, School of Medicine, Catholic University of Chile, Santiago de Chile. dmezzano@med.puc.cl

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Source

Thrombosis and haemostasis 81:6 1999 Jun pg 913-7

MeSH

Adult
Cardiovascular Diseases
Carrier Proteins
Diet, Vegetarian
Female
Hemostasis
Homocysteine
Humans
Male
Middle Aged
Risk Factors
alpha 1-Antitrypsin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10404767

Citation

Mezzano, D, et al. "Vegetarians and Cardiovascular Risk Factors: Hemostasis, Inflammatory Markers and Plasma Homocysteine." Thrombosis and Haemostasis, vol. 81, no. 6, 1999, pp. 913-7.
Mezzano D, Muñoz X, Martínez C, et al. Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine. Thromb Haemost. 1999;81(6):913-7.
Mezzano, D., Muñoz, X., Martínez, C., Cuevas, A., Panes, O., Aranda, E., ... Leighton, F. (1999). Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine. Thrombosis and Haemostasis, 81(6), pp. 913-7.
Mezzano D, et al. Vegetarians and Cardiovascular Risk Factors: Hemostasis, Inflammatory Markers and Plasma Homocysteine. Thromb Haemost. 1999;81(6):913-7. PubMed PMID: 10404767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine. AU - Mezzano,D, AU - Muñoz,X, AU - Martínez,C, AU - Cuevas,A, AU - Panes,O, AU - Aranda,E, AU - Guasch,V, AU - Strobel,P, AU - Muñoz,B, AU - Rodríguez,S, AU - Pereira,J, AU - Leighton,F, PY - 1999/7/15/pubmed PY - 1999/7/15/medline PY - 1999/7/15/entrez SP - 913 EP - 7 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 81 IS - 6 N2 - We studied hemostatic and inflammatory cardiovascular risk factors (CVRF), and total plasma homocysteine (tHcy) in 26 vegetarians (23 lacto- or ovolactovegetarians and 3 vegans), matched by age, sex and socioeconomic status with omnivorous controls. Vegetarians had significantly lower proportion of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in plasma lipids, significantly shortened bleeding time, and increased blood platelet count and in vitro platelet function (aggregation and secretion). Plasma levels of all coagulation or fibrinolytic factors and natural inhibitors synthesized in the liver were lower in vegetarians than in controls. Whereas for some factors this decrease was statistically significant (fibrinogen, factor VIIc, antithrombin III, protein S, plasminogen) for the remaining (factors VIIIc, Vc, prothrombin, protein C) a trend in the same direction was found. For hemostatic proteins of predominantly extrahepatic origin (von Willebrand factor. tPA, PAI-1) this tendency was not present. No significant differences in inflammatory proteins (C-reactive protein and alpha1-protease inhibitor) were detected in both groups. tHcy was significantly increased in vegetarians, and correlated only with cobalamin levels. The increased platelet function and tHcy found in vegetarians may counteract the known cardiovascular health benefits of vegetarian diet (VD). SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/10404767/full_citation L2 - https://medlineplus.gov/vegetariandiet.html DB - PRIME DP - Unbound Medicine ER -