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Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance.

Abstract

OBJECTIVE

To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.

DESIGN

Randomized clinical study.

SUBJECTS

A total of 186 subjects with impaired glucose tolerance and obesity.

INTERVENTIONS

The intervention programme included a low-fat, high-fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one-month learning and training session using different behavioural modification techniques and conducted in a full-board wellness centre (intense intervention group). The other half (n = 93) was randomized a one-hour counselling session with a specially trained nurse (usual care group). Follow-up was carried out after 12 months.

MAIN OUTCOME MEASURES

Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow-up after 1 year.

RESULTS

The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI-1 activity decreased 31% (-10.1 U mL(-1)), which was significantly more than in the usual care group (12%; -3.0 U mL(-1)). The corresponding reductions in tPA antigen were 14% (-1.65 microg L(-1)) and 6% (-0.69 microg L(-1)).

CONCLUSIONS

The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis.

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  • Authors+Show Affiliations

    ,

    Department of Nutritional Research, Umeå University, Sweden. bernt.lindahl@medicin.umu.se

    , , ,

    Source

    Journal of internal medicine 246:1 1999 Jul pg 105-12

    MeSH

    Adult
    Antigens
    Behavior Therapy
    Blood Glucose
    Body Weight
    Dietary Fats
    Dietary Fiber
    Exercise
    Female
    Fibrinogen
    Fibrinolysis
    Glucose Tolerance Test
    Humans
    Insulin
    Life Style
    Male
    Middle Aged
    Oxygen Consumption
    Patient Education as Topic
    Plasminogen Activator Inhibitor 1
    Tissue Plasminogen Activator

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10447232

    Citation

    Lindahl, B, et al. "Improved Fibrinolysis By Intense Lifestyle Intervention. a Randomized Trial in Subjects With Impaired Glucose Tolerance." Journal of Internal Medicine, vol. 246, no. 1, 1999, pp. 105-12.
    Lindahl B, Nilsson TK, Jansson JH, et al. Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. J Intern Med. 1999;246(1):105-12.
    Lindahl, B., Nilsson, T. K., Jansson, J. H., Asplund, K., & Hallmans, G. (1999). Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. Journal of Internal Medicine, 246(1), pp. 105-12.
    Lindahl B, et al. Improved Fibrinolysis By Intense Lifestyle Intervention. a Randomized Trial in Subjects With Impaired Glucose Tolerance. J Intern Med. 1999;246(1):105-12. PubMed PMID: 10447232.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. AU - Lindahl,B, AU - Nilsson,T K, AU - Jansson,J H, AU - Asplund,K, AU - Hallmans,G, PY - 1999/8/14/pubmed PY - 1999/8/14/medline PY - 1999/8/14/entrez SP - 105 EP - 12 JF - Journal of internal medicine JO - J. Intern. Med. VL - 246 IS - 1 N2 - OBJECTIVE: To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis. DESIGN: Randomized clinical study. SUBJECTS: A total of 186 subjects with impaired glucose tolerance and obesity. INTERVENTIONS: The intervention programme included a low-fat, high-fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one-month learning and training session using different behavioural modification techniques and conducted in a full-board wellness centre (intense intervention group). The other half (n = 93) was randomized a one-hour counselling session with a specially trained nurse (usual care group). Follow-up was carried out after 12 months. MAIN OUTCOME MEASURES: Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow-up after 1 year. RESULTS: The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI-1 activity decreased 31% (-10.1 U mL(-1)), which was significantly more than in the usual care group (12%; -3.0 U mL(-1)). The corresponding reductions in tPA antigen were 14% (-1.65 microg L(-1)) and 6% (-0.69 microg L(-1)). CONCLUSIONS: The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/10447232/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1999&volume=246&issue=1&spage=105 DB - PRIME DP - Unbound Medicine ER -