Tags

Type your tag names separated by a space and hit enter

Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance.
J Intern Med 1999; 246(1):105-12JI

Abstract

OBJECTIVE

To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis.

DESIGN

Randomized clinical study.

SUBJECTS

A total of 186 subjects with impaired glucose tolerance and obesity.

INTERVENTIONS

The intervention programme included a low-fat, high-fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one-month learning and training session using different behavioural modification techniques and conducted in a full-board wellness centre (intense intervention group). The other half (n = 93) was randomized a one-hour counselling session with a specially trained nurse (usual care group). Follow-up was carried out after 12 months.

MAIN OUTCOME MEASURES

Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow-up after 1 year.

RESULTS

The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI-1 activity decreased 31% (-10.1 U mL(-1)), which was significantly more than in the usual care group (12%; -3.0 U mL(-1)). The corresponding reductions in tPA antigen were 14% (-1.65 microg L(-1)) and 6% (-0.69 microg L(-1)).

CONCLUSIONS

The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis.

Authors+Show Affiliations

Department of Nutritional Research, Umeå University, Sweden. bernt.lindahl@medicin.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10447232

Citation

Lindahl, B, et al. "Improved Fibrinolysis By Intense Lifestyle Intervention. a Randomized Trial in Subjects With Impaired Glucose Tolerance." Journal of Internal Medicine, vol. 246, no. 1, 1999, pp. 105-12.
Lindahl B, Nilsson TK, Jansson JH, et al. Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. J Intern Med. 1999;246(1):105-12.
Lindahl, B., Nilsson, T. K., Jansson, J. H., Asplund, K., & Hallmans, G. (1999). Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. Journal of Internal Medicine, 246(1), pp. 105-12.
Lindahl B, et al. Improved Fibrinolysis By Intense Lifestyle Intervention. a Randomized Trial in Subjects With Impaired Glucose Tolerance. J Intern Med. 1999;246(1):105-12. PubMed PMID: 10447232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. AU - Lindahl,B, AU - Nilsson,T K, AU - Jansson,J H, AU - Asplund,K, AU - Hallmans,G, PY - 1999/8/14/pubmed PY - 1999/8/14/medline PY - 1999/8/14/entrez SP - 105 EP - 12 JF - Journal of internal medicine JO - J. Intern. Med. VL - 246 IS - 1 N2 - OBJECTIVE: To assess the effects of lifestyle intervention on cardiovascular risk factors in general and especially on fibrinolysis. DESIGN: Randomized clinical study. SUBJECTS: A total of 186 subjects with impaired glucose tolerance and obesity. INTERVENTIONS: The intervention programme included a low-fat, high-fibre diet and regular physical exercise. Half of the participants (n = 93) took part in a one-month learning and training session using different behavioural modification techniques and conducted in a full-board wellness centre (intense intervention group). The other half (n = 93) was randomized a one-hour counselling session with a specially trained nurse (usual care group). Follow-up was carried out after 12 months. MAIN OUTCOME MEASURES: Body weight, oxygen consumption, plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) antigen, fibrinogen and fasting plasma insulin measured at the start of the programme and at follow-up after 1 year. RESULTS: The intense intervention group had a mean weight decline by 1 year of 5.4 kg compared to 0.5 kg in the usual care group. Oxygen consumption in the intense group increased 10% vs. a 1% decline in the usual care group. In the intense group, PAI-1 activity decreased 31% (-10.1 U mL(-1)), which was significantly more than in the usual care group (12%; -3.0 U mL(-1)). The corresponding reductions in tPA antigen were 14% (-1.65 microg L(-1)) and 6% (-0.69 microg L(-1)). CONCLUSIONS: The present randomized study shows that an intense lifestyle programme has sustained beneficial effects on fibrinolysis. SN - 0954-6820 UR - http://www.unboundmedicine.com/medline/citation/10447232/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1999&volume=246&issue=1&spage=105 DB - PRIME DP - Unbound Medicine ER -