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Dietary fat and prostate cancer survival.

Abstract

OBJECTIVES

Relationships between dietary factors and the incidence of prostate cancer have emerged from epidemiologic and laboratory studies, but there are no published data on the relationship between diet and disease progression among prostate cancer patients. We studied the association between dietary fat intake and prostate cancer survival.

METHODS

We prospectively followed 384 men diagnosed with prostate cancer between 1990 and 1992 in the Quebec City area. On average 3 months following diagnosis, trained nutritionists interviewed the men on their usual diet using a diet history questionnaire. Deaths during follow-up were documented through record linkage with the provincial mortality file and review of hospital records. Cox proportional hazard models were used to estimate the relative risk of dying from prostate cancer associated with terciles of fat intake, expressed as percent of dietary energy, while controlling for prognostic factors and total energy.

RESULTS

The median duration of follow-up was 5.2 years. During the follow-up period 32 patients died of prostate cancer and 39 died of other causes. After controlling for grade, clinical stage, initial treatment, age and total energy intake, we found that saturated fat consumption was significantly associated with disease-specific survival (two-sided p-value = 0.008). Compared to men in the lower tercile of saturated fat, those in the upper tercile had three times the risk of dying from prostate cancer (relative risk = 3.1, 95% confidence interval: 1.3-7.7).

CONCLUSIONS

Our findings suggest that saturated fat is related to disease-specific survival and that, if this relation is causal, a moderate reduction of its intake might reduce the risk of dying from prostate cancer.

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  • Authors+Show Affiliations

    ,

    Department of Social and Preventive Medicine, Laval University, Laval University Cancer Research Centre, Quebec City, Canada.

    , , ,

    Source

    Cancer causes & control : CCC 10:4 1999 Aug pg 245-51

    MeSH

    Aged
    Cohort Studies
    Dietary Fats
    Disease-Free Survival
    Follow-Up Studies
    Humans
    Incidence
    Interviews as Topic
    Male
    Middle Aged
    Prognosis
    Proportional Hazards Models
    Prospective Studies
    Prostatic Neoplasms
    Quebec
    Risk Factors
    Severity of Illness Index
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10482482

    Citation

    Meyer, F, et al. "Dietary Fat and Prostate Cancer Survival." Cancer Causes & Control : CCC, vol. 10, no. 4, 1999, pp. 245-51.
    Meyer F, Bairati I, Shadmani R, et al. Dietary fat and prostate cancer survival. Cancer Causes Control. 1999;10(4):245-51.
    Meyer, F., Bairati, I., Shadmani, R., Fradet, Y., & Moore, L. (1999). Dietary fat and prostate cancer survival. Cancer Causes & Control : CCC, 10(4), pp. 245-51.
    Meyer F, et al. Dietary Fat and Prostate Cancer Survival. Cancer Causes Control. 1999;10(4):245-51. PubMed PMID: 10482482.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat and prostate cancer survival. AU - Meyer,F, AU - Bairati,I, AU - Shadmani,R, AU - Fradet,Y, AU - Moore,L, PY - 1999/9/11/pubmed PY - 1999/9/11/medline PY - 1999/9/11/entrez SP - 245 EP - 51 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 10 IS - 4 N2 - OBJECTIVES: Relationships between dietary factors and the incidence of prostate cancer have emerged from epidemiologic and laboratory studies, but there are no published data on the relationship between diet and disease progression among prostate cancer patients. We studied the association between dietary fat intake and prostate cancer survival. METHODS: We prospectively followed 384 men diagnosed with prostate cancer between 1990 and 1992 in the Quebec City area. On average 3 months following diagnosis, trained nutritionists interviewed the men on their usual diet using a diet history questionnaire. Deaths during follow-up were documented through record linkage with the provincial mortality file and review of hospital records. Cox proportional hazard models were used to estimate the relative risk of dying from prostate cancer associated with terciles of fat intake, expressed as percent of dietary energy, while controlling for prognostic factors and total energy. RESULTS: The median duration of follow-up was 5.2 years. During the follow-up period 32 patients died of prostate cancer and 39 died of other causes. After controlling for grade, clinical stage, initial treatment, age and total energy intake, we found that saturated fat consumption was significantly associated with disease-specific survival (two-sided p-value = 0.008). Compared to men in the lower tercile of saturated fat, those in the upper tercile had three times the risk of dying from prostate cancer (relative risk = 3.1, 95% confidence interval: 1.3-7.7). CONCLUSIONS: Our findings suggest that saturated fat is related to disease-specific survival and that, if this relation is causal, a moderate reduction of its intake might reduce the risk of dying from prostate cancer. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/10482482/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10482482.ui DB - PRIME DP - Unbound Medicine ER -