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Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group.

Abstract

OBJECTIVE

To explore whether perinatal factors are associated with the development of childhood type 1 diabetes.

RESEARCH DESIGN AND METHODS

We studied hospital records from 892 cases of childhood type 1 diabetes compared with 2,291 population-based control subjects in seven study centers in Europe.

RESULTS

In a pooled analysis incorporating stratification by center, we confirmed the previous findings that older maternal age, maternal preeclampsia, neonatal respiratory disease, and jaundice caused by blood group incompatibility are significant risk factors for type 1 diabetes, whereas being a firstborn child, having a low birth weight, or having a short birth length were protective. Cesarean section delivery and neonatal infectious diseases were not significantly associated with the risk of type 1 diabetes in this study. The strongest association was found for blood group incompatibility (AB0 and Rh factor) with an odds ratio (OR) of 2.96 (95% CI 1.88-4.65). AB0 incompatibility (OR = 3.92) was a more common and also a stronger risk factor than Rh incompatibility (OR = 1.62). The effect of AB0 blood group incompatibility was independent of treatment effects in logistical regression analysis.

CONCLUSIONS

Different perinatal events are associated with an increased risk of type 1 diabetes. The effect of maternal-child blood group incompatibility is strong and indicates a true effect that must be further explored.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Umeå University Hospital, Sweden. gisela.dahlquist@pediatri.umu.se

    ,

    Source

    Diabetes care 22:10 1999 Oct pg 1698-702

    MeSH

    ABO Blood-Group System
    Adult
    Blood Group Incompatibility
    Child
    Diabetes Mellitus, Type 1
    Europe
    Female
    Hospital Records
    Humans
    Infant, Newborn
    Maternal Age
    Odds Ratio
    Pre-Eclampsia
    Pregnancy
    Pregnancy, High-Risk
    Reference Values
    Regression Analysis
    Respiratory Tract Diseases
    Rh-Hr Blood-Group System
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    10526738

    Citation

    Dahlquist, G G., et al. "Perinatal Risk Factors for Childhood Type 1 Diabetes in Europe. the EURODIAB Substudy 2 Study Group." Diabetes Care, vol. 22, no. 10, 1999, pp. 1698-702.
    Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care. 1999;22(10):1698-702.
    Dahlquist, G. G., Patterson, C., & Soltesz, G. (1999). Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care, 22(10), pp. 1698-702.
    Dahlquist GG, Patterson C, Soltesz G. Perinatal Risk Factors for Childhood Type 1 Diabetes in Europe. the EURODIAB Substudy 2 Study Group. Diabetes Care. 1999;22(10):1698-702. PubMed PMID: 10526738.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. AU - Dahlquist,G G, AU - Patterson,C, AU - Soltesz,G, PY - 1999/10/20/pubmed PY - 1999/10/20/medline PY - 1999/10/20/entrez SP - 1698 EP - 702 JF - Diabetes care JO - Diabetes Care VL - 22 IS - 10 N2 - OBJECTIVE: To explore whether perinatal factors are associated with the development of childhood type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied hospital records from 892 cases of childhood type 1 diabetes compared with 2,291 population-based control subjects in seven study centers in Europe. RESULTS: In a pooled analysis incorporating stratification by center, we confirmed the previous findings that older maternal age, maternal preeclampsia, neonatal respiratory disease, and jaundice caused by blood group incompatibility are significant risk factors for type 1 diabetes, whereas being a firstborn child, having a low birth weight, or having a short birth length were protective. Cesarean section delivery and neonatal infectious diseases were not significantly associated with the risk of type 1 diabetes in this study. The strongest association was found for blood group incompatibility (AB0 and Rh factor) with an odds ratio (OR) of 2.96 (95% CI 1.88-4.65). AB0 incompatibility (OR = 3.92) was a more common and also a stronger risk factor than Rh incompatibility (OR = 1.62). The effect of AB0 blood group incompatibility was independent of treatment effects in logistical regression analysis. CONCLUSIONS: Different perinatal events are associated with an increased risk of type 1 diabetes. The effect of maternal-child blood group incompatibility is strong and indicates a true effect that must be further explored. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/10526738/full_citation L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=10526738 DB - PRIME DP - Unbound Medicine ER -