Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese.Eur J Clin Nutr. 1999 Nov; 53(11):886-90.EJ
OBJECTIVE
To investigate the effect of sodium, protein and calcium in habitual diets on bone resorption.
DESIGN
A cross-sectional study.
SETTING
A community-based study.
SUBJECTS
Healthy free-living male (n=342) and female (n=421) volunteers aged 20-79 y recruited for a health and nutrition examination survey conducted by a local government.
METHODS
Bone resorption was assessed by the measurement of free deoxypyridinoline in 24 h urine. Dietary assessment was by one-day dietary record method. Sodium and urea in 24 h urine were also measured for assessment of sodium and protein intake. The relationships between deoxypyridinoline excretion and the dietary factors were examined using correlation and multiple regression statistics.
RESULTS
In women aged 50-79 y, protein intake was positively associated with deoxypyridinoline excretion (P<0.05); and the urinary deoxypyridinoline/creatinine ratio was positively associated with both the urinary calcium/creatinine ratio (P<0.01) and sodium/creatinine ratio (P<0.05). In the multiple regression model, the association of the deoxypyridinoline/creatinine ratio and sodium/creatinine ratio was still significant (P<0.05) after adjustment for possible confounders, in this sex and age group.
CONCLUSION
In elderly women, habitual excess sodium in diets may result in bone loss through accelerated bone resorption.
