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Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese.

Abstract

OBJECTIVE

To investigate the effect of sodium, protein and calcium in habitual diets on bone resorption.

DESIGN

A cross-sectional study.

SETTING

A community-based study.

SUBJECTS

Healthy free-living male (n=342) and female (n=421) volunteers aged 20-79 y recruited for a health and nutrition examination survey conducted by a local government.

METHODS

Bone resorption was assessed by the measurement of free deoxypyridinoline in 24 h urine. Dietary assessment was by one-day dietary record method. Sodium and urea in 24 h urine were also measured for assessment of sodium and protein intake. The relationships between deoxypyridinoline excretion and the dietary factors were examined using correlation and multiple regression statistics.

RESULTS

In women aged 50-79 y, protein intake was positively associated with deoxypyridinoline excretion (P<0.05); and the urinary deoxypyridinoline/creatinine ratio was positively associated with both the urinary calcium/creatinine ratio (P<0.01) and sodium/creatinine ratio (P<0.05). In the multiple regression model, the association of the deoxypyridinoline/creatinine ratio and sodium/creatinine ratio was still significant (P<0.05) after adjustment for possible confounders, in this sex and age group.

CONCLUSION

In elderly women, habitual excess sodium in diets may result in bone loss through accelerated bone resorption.

Authors+Show Affiliations

,

Department of Home Economics, Tokyo Kasei Gakuin University.

, ,

Source

MeSH

Adult
Aged
Aging
Amino Acids
Analysis of Variance
Bone Resorption
Calcium
Calcium, Dietary
Creatinine
Cross-Sectional Studies
Dietary Proteins
Female
Humans
Japan
Male
Middle Aged
Sodium
Sodium, Dietary
Urea

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10557002

Citation

Itoh, R, et al. "Dietary Sodium, an Independent Determinant for Urinary Deoxypyridinoline in Elderly Women. a Cross-sectional Study On the Effect of Dietary Factors On Deoxypyridinoline Excretion in 24-h Urine Specimens From 763 Free-living Healthy Japanese." European Journal of Clinical Nutrition, vol. 53, no. 11, 1999, pp. 886-90.
Itoh R, Suyama Y, Oguma Y, et al. Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese. Eur J Clin Nutr. 1999;53(11):886-90.
Itoh, R., Suyama, Y., Oguma, Y., & Yokota, F. (1999). Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese. European Journal of Clinical Nutrition, 53(11), pp. 886-90.
Itoh R, et al. Dietary Sodium, an Independent Determinant for Urinary Deoxypyridinoline in Elderly Women. a Cross-sectional Study On the Effect of Dietary Factors On Deoxypyridinoline Excretion in 24-h Urine Specimens From 763 Free-living Healthy Japanese. Eur J Clin Nutr. 1999;53(11):886-90. PubMed PMID: 10557002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary sodium, an independent determinant for urinary deoxypyridinoline in elderly women. A cross-sectional study on the effect of dietary factors on deoxypyridinoline excretion in 24-h urine specimens from 763 free-living healthy Japanese. AU - Itoh,R, AU - Suyama,Y, AU - Oguma,Y, AU - Yokota,F, PY - 1999/11/11/pubmed PY - 1999/11/11/medline PY - 1999/11/11/entrez SP - 886 EP - 90 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 53 IS - 11 N2 - OBJECTIVE: To investigate the effect of sodium, protein and calcium in habitual diets on bone resorption. DESIGN: A cross-sectional study. SETTING: A community-based study. SUBJECTS: Healthy free-living male (n=342) and female (n=421) volunteers aged 20-79 y recruited for a health and nutrition examination survey conducted by a local government. METHODS: Bone resorption was assessed by the measurement of free deoxypyridinoline in 24 h urine. Dietary assessment was by one-day dietary record method. Sodium and urea in 24 h urine were also measured for assessment of sodium and protein intake. The relationships between deoxypyridinoline excretion and the dietary factors were examined using correlation and multiple regression statistics. RESULTS: In women aged 50-79 y, protein intake was positively associated with deoxypyridinoline excretion (P<0.05); and the urinary deoxypyridinoline/creatinine ratio was positively associated with both the urinary calcium/creatinine ratio (P<0.01) and sodium/creatinine ratio (P<0.05). In the multiple regression model, the association of the deoxypyridinoline/creatinine ratio and sodium/creatinine ratio was still significant (P<0.05) after adjustment for possible confounders, in this sex and age group. CONCLUSION: In elderly women, habitual excess sodium in diets may result in bone loss through accelerated bone resorption. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10557002/full_citation L2 - https://medlineplus.gov/seniorshealth.html DB - PRIME DP - Unbound Medicine ER -