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Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study.

Abstract

Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. We have therefore estimated the independent increase in lung cancer incidence in patients with cryptogenic fibrosing alveolitis compared with the general population in a population-based cohort study involving 890 subjects with cryptogenic fibrosing alveolitis and 5, 884 control subjects drawn from the United Kingdom General Practice Research Database. The incidence of lung cancer was markedly increased among patients with cryptogenic fibrosing alveolitis (rate ratio [RR] 7.31, 95% confidence interval [95% CI] 4.47 to 11.93, p < 0.001), and adjustment for previous smoking history had little effect on this odds ratio (adjusted RR: 8.25, 95% CI 4.70 to 11.48, p < 0.001). This increase in lung cancer incidence remained when the analysis was restricted to current smokers (RR 7.36, 95% CI 1.54 to 35.19, p = 0.012). This study provides clear evidence that the incidence of lung cancer is increased in patients with cryptogenic fibrosing alveolitis, and that this effect is independent of the effect of cigarette smoking.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Respiratory Medicine, Nottingham University, Nottingham, United Kingdom. Richard.Hubbard@Nottingham.ac.uk

    , ,

    Source

    MeSH

    Aged
    Cohort Studies
    Confidence Intervals
    Female
    Humans
    Incidence
    Lung Neoplasms
    Male
    Middle Aged
    Population Surveillance
    Pulmonary Fibrosis
    Retrospective Studies
    Risk Factors
    Smoking
    United Kingdom

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10619790

    Citation

    Hubbard, R, et al. "Lung Cancer and Cryptogenic Fibrosing Alveolitis. a Population-based Cohort Study." American Journal of Respiratory and Critical Care Medicine, vol. 161, no. 1, 2000, pp. 5-8.
    Hubbard R, Venn A, Lewis S, et al. Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med. 2000;161(1):5-8.
    Hubbard, R., Venn, A., Lewis, S., & Britton, J. (2000). Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. American Journal of Respiratory and Critical Care Medicine, 161(1), pp. 5-8.
    Hubbard R, et al. Lung Cancer and Cryptogenic Fibrosing Alveolitis. a Population-based Cohort Study. Am J Respir Crit Care Med. 2000;161(1):5-8. PubMed PMID: 10619790.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. AU - Hubbard,R, AU - Venn,A, AU - Lewis,S, AU - Britton,J, PY - 2000/1/5/pubmed PY - 2000/3/4/medline PY - 2000/1/5/entrez SP - 5 EP - 8 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 161 IS - 1 N2 - Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. We have therefore estimated the independent increase in lung cancer incidence in patients with cryptogenic fibrosing alveolitis compared with the general population in a population-based cohort study involving 890 subjects with cryptogenic fibrosing alveolitis and 5, 884 control subjects drawn from the United Kingdom General Practice Research Database. The incidence of lung cancer was markedly increased among patients with cryptogenic fibrosing alveolitis (rate ratio [RR] 7.31, 95% confidence interval [95% CI] 4.47 to 11.93, p < 0.001), and adjustment for previous smoking history had little effect on this odds ratio (adjusted RR: 8.25, 95% CI 4.70 to 11.48, p < 0.001). This increase in lung cancer incidence remained when the analysis was restricted to current smokers (RR 7.36, 95% CI 1.54 to 35.19, p = 0.012). This study provides clear evidence that the incidence of lung cancer is increased in patients with cryptogenic fibrosing alveolitis, and that this effect is independent of the effect of cigarette smoking. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/10619790/full_citation L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm.161.1.9906062?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -