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Total and resting energy expenditure in children with sickle cell disease.

Abstract

OBJECTIVE

To investigate energy balance in children with sickle cell disease (SCD) as the possible cause of impaired growth and undernutrition.

STUDY DESIGN

Growth, resting (REE), total (TEE), and activity-related (AEE) energy expenditure and dietary intake were examined in 36 African American children with SCD (20 girls and 16 boys) and 30 control subjects (15 girls and 15 boys) of similar age (mean, 11.2 years) and ethnicity. TEE was measured by means of the doubly labeled water technique and REE by indirect calorimetry. AEE was calculated as TEE minus REE. Fat free mass (FFM) was calculated from skinfold prediction equations.

RESULTS

REE was significantly increased (131 kcal/d) in children with SCD (P =.001), after adjusting for sex and FFM. Children with SCD tended to have lower TEE (214 kcal/d) than control subjects, but there was no difference after adjusting for FFM and sex (P =.57). Children with SCD had significantly (P =.025) lower AEE (268 kcal/d) but only marginally (P =.08) lower AEE after adjusting for FFM and sex.

CONCLUSIONS

The elevated REE and lower AEE, in combination with poor growth status, indicate chronic energy deficiency in children with SCD. Further studies are needed to determine the best approaches to the treatment and prevention of undernutrition in children with SCD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Anthropology, University of Pennsylvania, Philadelphia, USA.

    , , , ,

    Source

    The Journal of pediatrics 136:1 2000 Jan pg 73-9

    MeSH

    Analysis of Variance
    Anemia, Sickle Cell
    Body Height
    Body Mass Index
    Body Weight
    Calorimetry, Indirect
    Case-Control Studies
    Child
    Diet
    Energy Intake
    Energy Metabolism
    Female
    Growth Disorders
    Humans
    Male
    Motor Activity
    Muscle, Skeletal
    Nutrition Disorders
    Nutritional Status
    Rest
    Sex Factors
    Skinfold Thickness

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10636978

    Citation

    TY - JOUR T1 - Total and resting energy expenditure in children with sickle cell disease. AU - Barden,E M, AU - Zemel,B S, AU - Kawchak,D A, AU - Goran,M I, AU - Ohene-Frempong,K, AU - Stallings,V A, PY - 2000/1/15/pubmed PY - 2000/2/19/medline PY - 2000/1/15/entrez SP - 73 EP - 9 JF - The Journal of pediatrics JO - J. Pediatr. VL - 136 IS - 1 N2 - OBJECTIVE: To investigate energy balance in children with sickle cell disease (SCD) as the possible cause of impaired growth and undernutrition. STUDY DESIGN: Growth, resting (REE), total (TEE), and activity-related (AEE) energy expenditure and dietary intake were examined in 36 African American children with SCD (20 girls and 16 boys) and 30 control subjects (15 girls and 15 boys) of similar age (mean, 11.2 years) and ethnicity. TEE was measured by means of the doubly labeled water technique and REE by indirect calorimetry. AEE was calculated as TEE minus REE. Fat free mass (FFM) was calculated from skinfold prediction equations. RESULTS: REE was significantly increased (131 kcal/d) in children with SCD (P =.001), after adjusting for sex and FFM. Children with SCD tended to have lower TEE (214 kcal/d) than control subjects, but there was no difference after adjusting for FFM and sex (P =.57). Children with SCD had significantly (P =.025) lower AEE (268 kcal/d) but only marginally (P =.08) lower AEE after adjusting for FFM and sex. CONCLUSIONS: The elevated REE and lower AEE, in combination with poor growth status, indicate chronic energy deficiency in children with SCD. Further studies are needed to determine the best approaches to the treatment and prevention of undernutrition in children with SCD. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/10636978/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S0022-3476(00)90053-2 ER -