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Adult nutrient intake as a risk factor for Parkinson's disease.

Abstract

BACKGROUND

This population-based case-control study evaluated nutrient intake as a risk factor for Parkinson's disease (PD) among people aged > or =50 years in metropolitan Detroit.

METHODS

Cases (n = 126) were diagnosed between 1991 and 1995 and neurologist-confirmed. Controls (n = 432) were frequency-matched for sex, age (+/-5 years) and race. Using a standardized food frequency questionnaire, subjects reported the foods they ate within the past year.

RESULTS

Estimating the association between PD and risk of being in the highest versus the lowest intake quartile, there were elevated odds ratios for total fat (OR 1.94, 95% confidence interval [CI] : 1.05-3.58), cholesterol (OR 2.11, 95% CI: 1.14-3.90), lutein (OR 2.52, 95% CI: 1.32-4.84) and iron (OR 1.88, 95% CI: 1.05-3.38).

CONCLUSIONS

These results suggest an association of PD with high intake of total fat, saturated fats, cholesterol, lutein and iron.

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    MeSH

    Aged
    Aged, 80 and over
    Body Mass Index
    Case-Control Studies
    Dietary Fats
    Eating
    Energy Intake
    Female
    Food Habits
    Humans
    Lutein
    Male
    Michigan
    Middle Aged
    Nutrition Surveys
    Parkinson Disease
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10661654

    Citation

    TY - JOUR T1 - Adult nutrient intake as a risk factor for Parkinson's disease. AU - Johnson,C C, AU - Gorell,J M, AU - Rybicki,B A, AU - Sanders,K, AU - Peterson,E L, PY - 2000/2/8/pubmed PY - 2000/3/4/medline PY - 2000/2/8/entrez SP - 1102 EP - 9 JF - International journal of epidemiology JO - Int J Epidemiol VL - 28 IS - 6 N2 - BACKGROUND: This population-based case-control study evaluated nutrient intake as a risk factor for Parkinson's disease (PD) among people aged > or =50 years in metropolitan Detroit. METHODS: Cases (n = 126) were diagnosed between 1991 and 1995 and neurologist-confirmed. Controls (n = 432) were frequency-matched for sex, age (+/-5 years) and race. Using a standardized food frequency questionnaire, subjects reported the foods they ate within the past year. RESULTS: Estimating the association between PD and risk of being in the highest versus the lowest intake quartile, there were elevated odds ratios for total fat (OR 1.94, 95% confidence interval [CI] : 1.05-3.58), cholesterol (OR 2.11, 95% CI: 1.14-3.90), lutein (OR 2.52, 95% CI: 1.32-4.84) and iron (OR 1.88, 95% CI: 1.05-3.38). CONCLUSIONS: These results suggest an association of PD with high intake of total fat, saturated fats, cholesterol, lutein and iron. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/10661654/full_citation L2 - http://ije.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=10661654 ER -