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Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms.
Obstet Gynecol 2000; 95(2):245-50OG

Abstract

OBJECTIVE

To test the hypothesis that a low-fat, vegetarian diet reduces dysmenorrhea and premenstrual symptoms by its effect on serum sex-hormone binding globulin concentration and estrogen activity.

METHODS

In a crossover design, 33 women followed a low-fat, vegetarian diet for two menstrual cycles. For two additional cycles, they followed their customary diet while taking a supplement placebo pill. Dietary intake, serum sex-hormone binding globulin concentration, body weight, pain duration and intensity, and premenstrual symptoms were assessed during each study phase.

RESULTS

Mean (+/- standard deviation [SD]) serum sex-hormone binding globulin concentration was higher during the diet phase (46.7 +/- 23.6 nmol/L) than during the supplement phase (39.3 +/- 19.8 nmol/L, P < .001). Mean (+/- SD) body weight was lower during the diet (66.1 +/- 11.3 kg) compared with the supplement phase (67.9 +/- 12.1 kg, P < .001). Mean dysmenorrhea duration fell significantly from baseline (3.9 +/- 1.7 days) to diet phase (2.7 +/- 1.9 days) compared with change from baseline to supplement phase (3.6 +/- 1.7 days, P < .01). Pain intensity fell significantly during the diet phase, compared with baseline, for the worst, second-worst, and third-worst days, and mean durations of premenstrual concentration, behavioral change, and water retention symptoms were reduced significantly, compared with the supplement phase.

CONCLUSION

A low-fat vegetarian diet was associated with increased serum sex-hormone binding globulin concentration and reductions in body weight, dysmenorrhea duration and intensity, and premenstrual symptom duration. The symptom effects might be mediated by dietary influences on estrogen activity.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA. nbarnard@pcrm.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10674588

Citation

Barnard, N D., et al. "Diet and Sex-hormone Binding Globulin, Dysmenorrhea, and Premenstrual Symptoms." Obstetrics and Gynecology, vol. 95, no. 2, 2000, pp. 245-50.
Barnard ND, Scialli AR, Hurlock D, et al. Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstet Gynecol. 2000;95(2):245-50.
Barnard, N. D., Scialli, A. R., Hurlock, D., & Bertron, P. (2000). Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstetrics and Gynecology, 95(2), pp. 245-50.
Barnard ND, et al. Diet and Sex-hormone Binding Globulin, Dysmenorrhea, and Premenstrual Symptoms. Obstet Gynecol. 2000;95(2):245-50. PubMed PMID: 10674588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. AU - Barnard,N D, AU - Scialli,A R, AU - Hurlock,D, AU - Bertron,P, PY - 2000/2/16/pubmed PY - 2000/3/4/medline PY - 2000/2/16/entrez SP - 245 EP - 50 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 95 IS - 2 N2 - OBJECTIVE: To test the hypothesis that a low-fat, vegetarian diet reduces dysmenorrhea and premenstrual symptoms by its effect on serum sex-hormone binding globulin concentration and estrogen activity. METHODS: In a crossover design, 33 women followed a low-fat, vegetarian diet for two menstrual cycles. For two additional cycles, they followed their customary diet while taking a supplement placebo pill. Dietary intake, serum sex-hormone binding globulin concentration, body weight, pain duration and intensity, and premenstrual symptoms were assessed during each study phase. RESULTS: Mean (+/- standard deviation [SD]) serum sex-hormone binding globulin concentration was higher during the diet phase (46.7 +/- 23.6 nmol/L) than during the supplement phase (39.3 +/- 19.8 nmol/L, P < .001). Mean (+/- SD) body weight was lower during the diet (66.1 +/- 11.3 kg) compared with the supplement phase (67.9 +/- 12.1 kg, P < .001). Mean dysmenorrhea duration fell significantly from baseline (3.9 +/- 1.7 days) to diet phase (2.7 +/- 1.9 days) compared with change from baseline to supplement phase (3.6 +/- 1.7 days, P < .01). Pain intensity fell significantly during the diet phase, compared with baseline, for the worst, second-worst, and third-worst days, and mean durations of premenstrual concentration, behavioral change, and water retention symptoms were reduced significantly, compared with the supplement phase. CONCLUSION: A low-fat vegetarian diet was associated with increased serum sex-hormone binding globulin concentration and reductions in body weight, dysmenorrhea duration and intensity, and premenstrual symptom duration. The symptom effects might be mediated by dietary influences on estrogen activity. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/10674588/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029-7844(99)00525-6 DB - PRIME DP - Unbound Medicine ER -