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Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis.

Abstract

Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and municipality. Serum selenium and alpha-tocopherol concentrations were measured from stored serum samples collected at baseline. Serum selenium was inversely related to subsequent occurrence of rheumatoid factor-negative but not rheumatoid factor-positive rheumatoid arthritis. The relative risks, adjusted for smoking and serum total cholesterol, for the highest relative to the lowest tertile of serum selenium, were 0.16 [95% confidence interval (CI) = 0.04-0.69] for rheumatoid factor-negative and 0.96 (CI = 0.49-1.90) for rheumatoid factor-positive rheumatoid arthritis. During the first 10 years of follow-up, the relative risk for rheumatoid arthritis for the highest compared with the lowest tertile of serum alpha-tocopherol was 0.44 (CI = 0.19-0.99). No association was found for longer follow-up periods. Low selenium status may be a risk factor for rheumatoid factor-negative rheumatoid arthritis, and low alpha-tocopherol status may be a risk factor for rheumatoid arthritis independently of rheumatoid factor status.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    National Public Health Institute (KTL), Helsinki, Finland.

    , , , ,

    Source

    Epidemiology (Cambridge, Mass.) 11:4 2000 Jul pg 402-5

    MeSH

    Adult
    Aged
    Arthritis, Rheumatoid
    Biomarkers
    Cohort Studies
    Female
    Humans
    Male
    Middle Aged
    Nutritional Status
    Risk Assessment
    Selenium
    Vitamin E

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10874546

    Citation

    Knekt, P, et al. "Serum Selenium, Serum Alpha-tocopherol, and the Risk of Rheumatoid Arthritis." Epidemiology (Cambridge, Mass.), vol. 11, no. 4, 2000, pp. 402-5.
    Knekt P, Heliövaara M, Aho K, et al. Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology. 2000;11(4):402-5.
    Knekt, P., Heliövaara, M., Aho, K., Alfthan, G., Marniemi, J., & Aromaa, A. (2000). Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology (Cambridge, Mass.), 11(4), pp. 402-5.
    Knekt P, et al. Serum Selenium, Serum Alpha-tocopherol, and the Risk of Rheumatoid Arthritis. Epidemiology. 2000;11(4):402-5. PubMed PMID: 10874546.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. AU - Knekt,P, AU - Heliövaara,M, AU - Aho,K, AU - Alfthan,G, AU - Marniemi,J, AU - Aromaa,A, PY - 2000/6/30/pubmed PY - 2001/2/28/medline PY - 2000/6/30/entrez SP - 402 EP - 5 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 11 IS - 4 N2 - Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and municipality. Serum selenium and alpha-tocopherol concentrations were measured from stored serum samples collected at baseline. Serum selenium was inversely related to subsequent occurrence of rheumatoid factor-negative but not rheumatoid factor-positive rheumatoid arthritis. The relative risks, adjusted for smoking and serum total cholesterol, for the highest relative to the lowest tertile of serum selenium, were 0.16 [95% confidence interval (CI) = 0.04-0.69] for rheumatoid factor-negative and 0.96 (CI = 0.49-1.90) for rheumatoid factor-positive rheumatoid arthritis. During the first 10 years of follow-up, the relative risk for rheumatoid arthritis for the highest compared with the lowest tertile of serum alpha-tocopherol was 0.44 (CI = 0.19-0.99). No association was found for longer follow-up periods. Low selenium status may be a risk factor for rheumatoid factor-negative rheumatoid arthritis, and low alpha-tocopherol status may be a risk factor for rheumatoid arthritis independently of rheumatoid factor status. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/10874546/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=10874546 DB - PRIME DP - Unbound Medicine ER -