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Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis.
Epidemiology 2000; 11(4):402-5E

Abstract

Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and municipality. Serum selenium and alpha-tocopherol concentrations were measured from stored serum samples collected at baseline. Serum selenium was inversely related to subsequent occurrence of rheumatoid factor-negative but not rheumatoid factor-positive rheumatoid arthritis. The relative risks, adjusted for smoking and serum total cholesterol, for the highest relative to the lowest tertile of serum selenium, were 0.16 [95% confidence interval (CI) = 0.04-0.69] for rheumatoid factor-negative and 0.96 (CI = 0.49-1.90) for rheumatoid factor-positive rheumatoid arthritis. During the first 10 years of follow-up, the relative risk for rheumatoid arthritis for the highest compared with the lowest tertile of serum alpha-tocopherol was 0.44 (CI = 0.19-0.99). No association was found for longer follow-up periods. Low selenium status may be a risk factor for rheumatoid factor-negative rheumatoid arthritis, and low alpha-tocopherol status may be a risk factor for rheumatoid arthritis independently of rheumatoid factor status.

Authors+Show Affiliations

National Public Health Institute (KTL), Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10874546

Citation

Knekt, P, et al. "Serum Selenium, Serum Alpha-tocopherol, and the Risk of Rheumatoid Arthritis." Epidemiology (Cambridge, Mass.), vol. 11, no. 4, 2000, pp. 402-5.
Knekt P, Heliövaara M, Aho K, et al. Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology. 2000;11(4):402-5.
Knekt, P., Heliövaara, M., Aho, K., Alfthan, G., Marniemi, J., & Aromaa, A. (2000). Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. Epidemiology (Cambridge, Mass.), 11(4), pp. 402-5.
Knekt P, et al. Serum Selenium, Serum Alpha-tocopherol, and the Risk of Rheumatoid Arthritis. Epidemiology. 2000;11(4):402-5. PubMed PMID: 10874546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis. AU - Knekt,P, AU - Heliövaara,M, AU - Aho,K, AU - Alfthan,G, AU - Marniemi,J, AU - Aromaa,A, PY - 2000/6/30/pubmed PY - 2001/2/28/medline PY - 2000/6/30/entrez SP - 402 EP - 5 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 11 IS - 4 N2 - Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and municipality. Serum selenium and alpha-tocopherol concentrations were measured from stored serum samples collected at baseline. Serum selenium was inversely related to subsequent occurrence of rheumatoid factor-negative but not rheumatoid factor-positive rheumatoid arthritis. The relative risks, adjusted for smoking and serum total cholesterol, for the highest relative to the lowest tertile of serum selenium, were 0.16 [95% confidence interval (CI) = 0.04-0.69] for rheumatoid factor-negative and 0.96 (CI = 0.49-1.90) for rheumatoid factor-positive rheumatoid arthritis. During the first 10 years of follow-up, the relative risk for rheumatoid arthritis for the highest compared with the lowest tertile of serum alpha-tocopherol was 0.44 (CI = 0.19-0.99). No association was found for longer follow-up periods. Low selenium status may be a risk factor for rheumatoid factor-negative rheumatoid arthritis, and low alpha-tocopherol status may be a risk factor for rheumatoid arthritis independently of rheumatoid factor status. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/10874546/full_citation L2 - http://dx.doi.org/10.1097/00001648-200007000-00007 DB - PRIME DP - Unbound Medicine ER -