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Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study.

Abstract

BACKGROUND

Elevated blood levels of homocysteine are associated with an increased risk of atherosclerotic cardiovascular disease. Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied.

METHODS AND RESULTS

During a 3-week run-in, 118 participants were fed a control diet, low in fruits, vegetables, and dairy products, with a fat content typical of US consumption. During an 8-week intervention phase, participants were then fed 1 of 3 randomly assigned diets: the control diet, a diet rich in fruits and vegetables but otherwise similar to control, or a combination diet rich in fruits, vegetables, and low-fat dairy products and reduced in saturated and total fat. Between the end of run-in and intervention periods, mean change in homocysteine was +0.46 micromol/L in the control diet, +0.21 micromol/L in the fruits and vegetables diet (P=0.47 compared with control), and -0.34 micromol/L in the combination diet (P=0.03 compared with control, P=0.12 compared with the fruits and vegetables diet). In multivariable regression models, change in homocysteine was significantly and inversely associated with change in serum folate (P=0.03) but not with change in serum vitamin B(12) (P=0.64) or pyridoxal 5' phosphate, the coenzyme form of vitamin B(6) (P=0.83).

CONCLUSIONS

Modification of dietary patterns can have substantial effects on fasting levels of total serum homocysteine. These results provide additional insights into the mechanisms by which diet might influence the occurrence of atherosclerotic cardiovascular disease.

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  • Authors+Show Affiliations

    ,

    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA. lappel@welch.jhu.edu

    , , , , , ,

    Source

    Circulation 102:8 2000 Aug 22 pg 852-7

    MeSH

    Adult
    Aged
    Diet
    Dietary Fats
    Fasting
    Female
    Folic Acid
    Fruit
    Homocysteine
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Pyridoxal Phosphate
    Vegetables
    Vitamin B 12

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10952952

    Citation

    Appel, L J., et al. "Effect of Dietary Patterns On Serum Homocysteine: Results of a Randomized, Controlled Feeding Study." Circulation, vol. 102, no. 8, 2000, pp. 852-7.
    Appel LJ, Miller ER, Jee SH, et al. Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. Circulation. 2000;102(8):852-7.
    Appel, L. J., Miller, E. R., Jee, S. H., Stolzenberg-Solomon, R., Lin, P. H., Erlinger, T., ... Selhub, J. (2000). Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. Circulation, 102(8), pp. 852-7.
    Appel LJ, et al. Effect of Dietary Patterns On Serum Homocysteine: Results of a Randomized, Controlled Feeding Study. Circulation. 2000 Aug 22;102(8):852-7. PubMed PMID: 10952952.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. AU - Appel,L J, AU - Miller,E R,3rd AU - Jee,S H, AU - Stolzenberg-Solomon,R, AU - Lin,P H, AU - Erlinger,T, AU - Nadeau,M R, AU - Selhub,J, PY - 2000/8/23/pubmed PY - 2000/9/9/medline PY - 2000/8/23/entrez SP - 852 EP - 7 JF - Circulation JO - Circulation VL - 102 IS - 8 N2 - BACKGROUND: Elevated blood levels of homocysteine are associated with an increased risk of atherosclerotic cardiovascular disease. Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied. METHODS AND RESULTS: During a 3-week run-in, 118 participants were fed a control diet, low in fruits, vegetables, and dairy products, with a fat content typical of US consumption. During an 8-week intervention phase, participants were then fed 1 of 3 randomly assigned diets: the control diet, a diet rich in fruits and vegetables but otherwise similar to control, or a combination diet rich in fruits, vegetables, and low-fat dairy products and reduced in saturated and total fat. Between the end of run-in and intervention periods, mean change in homocysteine was +0.46 micromol/L in the control diet, +0.21 micromol/L in the fruits and vegetables diet (P=0.47 compared with control), and -0.34 micromol/L in the combination diet (P=0.03 compared with control, P=0.12 compared with the fruits and vegetables diet). In multivariable regression models, change in homocysteine was significantly and inversely associated with change in serum folate (P=0.03) but not with change in serum vitamin B(12) (P=0.64) or pyridoxal 5' phosphate, the coenzyme form of vitamin B(6) (P=0.83). CONCLUSIONS: Modification of dietary patterns can have substantial effects on fasting levels of total serum homocysteine. These results provide additional insights into the mechanisms by which diet might influence the occurrence of atherosclerotic cardiovascular disease. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/10952952/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10952952.ui DB - PRIME DP - Unbound Medicine ER -