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Hepatitis A.

Abstract

Hepatitis A remains an important cause of community-acquired hepatitis in the United States and in the world. In recent years, improvements in personal hygiene and environmental sanitation have led to declines in overall hepatitis A infection rates in developed countries, although sporadic outbreaks still occur with similar rates of hospitalization and loss of work. Therapy remains supportive and prevention holds the key to elimination of widespread infection. Acute infection can be prevented or attenuated with IG or with inactivated, highly immunogenic vaccines. Elderly persons and those with advanced liver disease are at higher risk of the consequences of acute HAV, and they represent target populations for immediate vaccination. Challenges for the future include strategies for broad-based population vaccination, including cost-effective approaches.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, University of Texas Medical Branch, Galveston, USA.

    Source

    MeSH

    Hepatitis A
    Hepatitis A Vaccines
    Hepatitis A Virus, Human
    Humans
    Hygiene
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    10987112

    Citation

    Kemmer, N M., and E P. Miskovsky. "Hepatitis A." Infectious Disease Clinics of North America, vol. 14, no. 3, 2000, pp. 605-15.
    Kemmer NM, Miskovsky EP. Hepatitis A. Infect Dis Clin North Am. 2000;14(3):605-15.
    Kemmer, N. M., & Miskovsky, E. P. (2000). Hepatitis A. Infectious Disease Clinics of North America, 14(3), pp. 605-15.
    Kemmer NM, Miskovsky EP. Hepatitis A. Infect Dis Clin North Am. 2000;14(3):605-15. PubMed PMID: 10987112.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis A. AU - Kemmer,N M, AU - Miskovsky,E P, PY - 2000/9/15/pubmed PY - 2001/3/3/medline PY - 2000/9/15/entrez SP - 605 EP - 15 JF - Infectious disease clinics of North America JO - Infect. Dis. Clin. North Am. VL - 14 IS - 3 N2 - Hepatitis A remains an important cause of community-acquired hepatitis in the United States and in the world. In recent years, improvements in personal hygiene and environmental sanitation have led to declines in overall hepatitis A infection rates in developed countries, although sporadic outbreaks still occur with similar rates of hospitalization and loss of work. Therapy remains supportive and prevention holds the key to elimination of widespread infection. Acute infection can be prevented or attenuated with IG or with inactivated, highly immunogenic vaccines. Elderly persons and those with advanced liver disease are at higher risk of the consequences of acute HAV, and they represent target populations for immediate vaccination. Challenges for the future include strategies for broad-based population vaccination, including cost-effective approaches. SN - 0891-5520 UR - https://www.unboundmedicine.com/medline/citation/10987112/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5520(05)70123-9 DB - PRIME DP - Unbound Medicine ER -