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Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk.

Abstract

The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (CI): 0.96, 1.10) in premenopausal women and 1.07 (95% CI: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% CI: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% CI: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Maastricht University, The Netherlands. PA.vandenBrandt@epid.uni-maas.nl

    , , , , , , , , , , , , , , , ,

    Source

    American journal of epidemiology 152:6 2000 Sep 15 pg 514-27

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Body Height
    Body Weight
    Breast Neoplasms
    Cohort Studies
    Female
    Humans
    Middle Aged
    Multivariate Analysis
    Postmenopause
    Premenopause
    Prospective Studies
    Regression Analysis
    Risk Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10997541

    Citation

    van den Brandt, P A., et al. "Pooled Analysis of Prospective Cohort Studies On Height, Weight, and Breast Cancer Risk." American Journal of Epidemiology, vol. 152, no. 6, 2000, pp. 514-27.
    van den Brandt PA, Spiegelman D, Yaun SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152(6):514-27.
    van den Brandt, P. A., Spiegelman, D., Yaun, S. S., Adami, H. O., Beeson, L., Folsom, A. R., ... Hunter, D. J. (2000). Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. American Journal of Epidemiology, 152(6), pp. 514-27.
    van den Brandt PA, et al. Pooled Analysis of Prospective Cohort Studies On Height, Weight, and Breast Cancer Risk. Am J Epidemiol. 2000 Sep 15;152(6):514-27. PubMed PMID: 10997541.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. AU - van den Brandt,P A, AU - Spiegelman,D, AU - Yaun,S S, AU - Adami,H O, AU - Beeson,L, AU - Folsom,A R, AU - Fraser,G, AU - Goldbohm,R A, AU - Graham,S, AU - Kushi,L, AU - Marshall,J R, AU - Miller,A B, AU - Rohan,T, AU - Smith-Warner,S A, AU - Speizer,F E, AU - Willett,W C, AU - Wolk,A, AU - Hunter,D J, PY - 2000/9/21/pubmed PY - 2000/9/30/medline PY - 2000/9/21/entrez SP - 514 EP - 27 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 152 IS - 6 N2 - The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (CI): 0.96, 1.10) in premenopausal women and 1.07 (95% CI: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% CI: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% CI: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/10997541/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/152.6.514 DB - PRIME DP - Unbound Medicine ER -