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Relationship between regional fat distribution and insulin resistance.

Abstract

Visceral fat is a strong predictor of insulin resistance in obese subjects, but not in normal weight individuals, suggesting that this association might occur only beyond a certain threshold of visceral fat amount. Unlike subcutaneous fat, increased visceral fat is associated with increased hepatic glucose production and reduced glucose disposal. This association is independent of the methodology used to assess insulin sensitivity in humans. This article reviews all relevant data coming from epidemiological, clinical and interventional (weight loss) studies and studies obtained in identical twins.

Authors+Show Affiliations

Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy. malmetab@borgotrento.univr.it

Source

MeSH

Adipose Tissue
Body Composition
Body Constitution
Female
Glucose
Humans
Insulin Resistance
Liver
Male
Obesity
Viscera

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10997605

Citation

Bonora, E. "Relationship Between Regional Fat Distribution and Insulin Resistance." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 24 Suppl 2, 2000, pp. S32-5.
Bonora E. Relationship between regional fat distribution and insulin resistance. Int J Obes Relat Metab Disord. 2000;24 Suppl 2:S32-5.
Bonora, E. (2000). Relationship between regional fat distribution and insulin resistance. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 24 Suppl 2, pp. S32-5.
Bonora E. Relationship Between Regional Fat Distribution and Insulin Resistance. Int J Obes Relat Metab Disord. 2000;24 Suppl 2:S32-5. PubMed PMID: 10997605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between regional fat distribution and insulin resistance. A1 - Bonora,E, PY - 2000/9/21/pubmed PY - 2000/10/14/medline PY - 2000/9/21/entrez SP - S32 EP - 5 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int. J. Obes. Relat. Metab. Disord. VL - 24 Suppl 2 N2 - Visceral fat is a strong predictor of insulin resistance in obese subjects, but not in normal weight individuals, suggesting that this association might occur only beyond a certain threshold of visceral fat amount. Unlike subcutaneous fat, increased visceral fat is associated with increased hepatic glucose production and reduced glucose disposal. This association is independent of the methodology used to assess insulin sensitivity in humans. This article reviews all relevant data coming from epidemiological, clinical and interventional (weight loss) studies and studies obtained in identical twins. UR - https://www.unboundmedicine.com/medline/citation/10997605/full_citation DB - PRIME DP - Unbound Medicine ER -