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Prevalence of thiamin deficiency in anorexia nervosa.
Int J Eat Disord 2000; 28(4):451-4IJ

Abstract

OBJECTIVE

Deficiency of thiamin (vitamin B1) causes a range of neuropsychiatric symptoms that resemble those reported in patients with anorexia nervosa (AN) but the prevalence of thiamin deficiency in AN has not been reliably established. This study was designed to investigate the prevalence of thiamin deficiency in AN.

METHOD

Thirty-seven patients attending a specialist eating disorders unit and meeting all or some of the DSM-IV criteria for AN were compared with 50 blood donor controls. All subjects underwent measurement of erythrocyte transketolase activation following the addition of thiamin pyrophosphate, the standard biochemical test for thiamin deficiency. Deficiency was defined as a result more than 2 SD above the mean of the control population.

RESULTS

Fourteen patients (38%) had results in the deficient range; 7 (19%) met the most stringent published criterion for deficiency. Deficiency was not related to duration of eating restraint, frequency of vomiting, or alcohol consumption.

DISCUSSION

Thiamin deficiency may account for some of the neuropsychiatric symptoms of AN and routine screening or supplementation may be indicated.

Authors+Show Affiliations

Department of Psychiatry, University of Leicester, United Kingdom. awinston@lgh.u-net.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11054793

Citation

Winston, A P., et al. "Prevalence of Thiamin Deficiency in Anorexia Nervosa." The International Journal of Eating Disorders, vol. 28, no. 4, 2000, pp. 451-4.
Winston AP, Jamieson CP, Madira W, et al. Prevalence of thiamin deficiency in anorexia nervosa. Int J Eat Disord. 2000;28(4):451-4.
Winston, A. P., Jamieson, C. P., Madira, W., Gatward, N. M., & Palmer, R. L. (2000). Prevalence of thiamin deficiency in anorexia nervosa. The International Journal of Eating Disorders, 28(4), pp. 451-4.
Winston AP, et al. Prevalence of Thiamin Deficiency in Anorexia Nervosa. Int J Eat Disord. 2000;28(4):451-4. PubMed PMID: 11054793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of thiamin deficiency in anorexia nervosa. AU - Winston,A P, AU - Jamieson,C P, AU - Madira,W, AU - Gatward,N M, AU - Palmer,R L, PY - 2000/10/31/pubmed PY - 2001/2/28/medline PY - 2000/10/31/entrez SP - 451 EP - 4 JF - The International journal of eating disorders JO - Int J Eat Disord VL - 28 IS - 4 N2 - OBJECTIVE: Deficiency of thiamin (vitamin B1) causes a range of neuropsychiatric symptoms that resemble those reported in patients with anorexia nervosa (AN) but the prevalence of thiamin deficiency in AN has not been reliably established. This study was designed to investigate the prevalence of thiamin deficiency in AN. METHOD: Thirty-seven patients attending a specialist eating disorders unit and meeting all or some of the DSM-IV criteria for AN were compared with 50 blood donor controls. All subjects underwent measurement of erythrocyte transketolase activation following the addition of thiamin pyrophosphate, the standard biochemical test for thiamin deficiency. Deficiency was defined as a result more than 2 SD above the mean of the control population. RESULTS: Fourteen patients (38%) had results in the deficient range; 7 (19%) met the most stringent published criterion for deficiency. Deficiency was not related to duration of eating restraint, frequency of vomiting, or alcohol consumption. DISCUSSION: Thiamin deficiency may account for some of the neuropsychiatric symptoms of AN and routine screening or supplementation may be indicated. SN - 0276-3478 UR - https://www.unboundmedicine.com/medline/citation/11054793/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0276-3478&date=2000&volume=28&issue=4&spage=451 DB - PRIME DP - Unbound Medicine ER -