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Breast feeding and the intestinal microflora of the infant--implications for protection against infectious diseases.
Adv Exp Med Biol 2000; 478:77-93AE

Abstract

Human breast milk contains an array of factors with anti-infectious potential, such as immunoglobulins (especially secretory IgA), oligosaccharides and glycoproteins with anti-adhesive capacity, and cytokines. Breast-feeding is associated with protection from the following infections or infection-related conditions: gastroenteritis, upper and lower respiratory tract infection, acute otitis media, urinary tract infection, neonatal septicaemia and necrotizing enterocolitis. Some of the protective effects may derive from an altered mucosal colonization pattern in the breast-fed infant. In other instances breast-fed infants develop less symptoms to the same microbe which causes disease in the bottle-fed infant. An example of an altered colonization pattern is that breast-fed infants have less P-fimbriated, but more type 1-fimbriated E. coli. This may protect against urinary tract infection in the breast-fed infant since P. fimbriae are the major virulence factor for urinary tract infection. An example of changed consequences of the same microbial colonization is that secretory IgA in the breast-milk protects very efficiently from translocation of intestinal bacteria across the gut mucosa by coating intestinal bacteria and blocking their interaction with the epithelium. This mechanism may protect the infant from septicaemia of gut origin and, possibly, necrotizing enterocolitis. Breast-milk is also highly anti-inflammatogenic and contains hormone like factors which counteract diarrhea. Thus, breast-fed infants may be colonized by recognized diarrheal pathogens and still remain healthy. Due to a less virulent intestinal microflora and decreased translocation breast-fed infants will obtain less stimuli for the gut immune system, resulting, in e.g., lower salivary IgA antibody titres.

Authors+Show Affiliations

Department of Clinical Immunology, Göteborg University, Sweden.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11065062

Citation

Wold, A E., and I Adlerberth. "Breast Feeding and the Intestinal Microflora of the Infant--implications for Protection Against Infectious Diseases." Advances in Experimental Medicine and Biology, vol. 478, 2000, pp. 77-93.
Wold AE, Adlerberth I. Breast feeding and the intestinal microflora of the infant--implications for protection against infectious diseases. Adv Exp Med Biol. 2000;478:77-93.
Wold, A. E., & Adlerberth, I. (2000). Breast feeding and the intestinal microflora of the infant--implications for protection against infectious diseases. Advances in Experimental Medicine and Biology, 478, pp. 77-93.
Wold AE, Adlerberth I. Breast Feeding and the Intestinal Microflora of the Infant--implications for Protection Against Infectious Diseases. Adv Exp Med Biol. 2000;478:77-93. PubMed PMID: 11065062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast feeding and the intestinal microflora of the infant--implications for protection against infectious diseases. AU - Wold,A E, AU - Adlerberth,I, PY - 2000/11/7/pubmed PY - 2001/10/12/medline PY - 2000/11/7/entrez SP - 77 EP - 93 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 478 N2 - Human breast milk contains an array of factors with anti-infectious potential, such as immunoglobulins (especially secretory IgA), oligosaccharides and glycoproteins with anti-adhesive capacity, and cytokines. Breast-feeding is associated with protection from the following infections or infection-related conditions: gastroenteritis, upper and lower respiratory tract infection, acute otitis media, urinary tract infection, neonatal septicaemia and necrotizing enterocolitis. Some of the protective effects may derive from an altered mucosal colonization pattern in the breast-fed infant. In other instances breast-fed infants develop less symptoms to the same microbe which causes disease in the bottle-fed infant. An example of an altered colonization pattern is that breast-fed infants have less P-fimbriated, but more type 1-fimbriated E. coli. This may protect against urinary tract infection in the breast-fed infant since P. fimbriae are the major virulence factor for urinary tract infection. An example of changed consequences of the same microbial colonization is that secretory IgA in the breast-milk protects very efficiently from translocation of intestinal bacteria across the gut mucosa by coating intestinal bacteria and blocking their interaction with the epithelium. This mechanism may protect the infant from septicaemia of gut origin and, possibly, necrotizing enterocolitis. Breast-milk is also highly anti-inflammatogenic and contains hormone like factors which counteract diarrhea. Thus, breast-fed infants may be colonized by recognized diarrheal pathogens and still remain healthy. Due to a less virulent intestinal microflora and decreased translocation breast-fed infants will obtain less stimuli for the gut immune system, resulting, in e.g., lower salivary IgA antibody titres. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/11065062/full_citation L2 - https://dx.doi.org/10.1007/0-306-46830-1_7 DB - PRIME DP - Unbound Medicine ER -