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Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study.
Blood Coagul Fibrinolysis 2000; 11(8):775-81BC

Abstract

Despite much research, the aetiology of venous disease is still poorly understood. Since haemostatic factors are involved in the processes of fibrinolysis and platelet aggregation, it is conceivable that such processes may be implicated in the pathology of varicose veins and chronic venous insufficiency (CVI). The Edinburgh Vein Study examined 1566 men and women aged 18-64 years that were randomly selected from the lists of 12 general practitioners. Each subject completed a questionnaire, underwent a comprehensive clinical examination and had a blood sample taken for the analysis of plasma fibrinogen, tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) antigens. Subjects with trunk varicose veins and those with CVI had higher levels of each haemostatic factor compared with those with no trunk varices and no CVI. Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance. However, this does not entirely rule out the possibility of a pathogenic role for haemostatic factors in venous disease, but rather indicates the need for further experimental and epidemiological studies.

Authors+Show Affiliations

Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Edinburgh, UK. Amanda.Lee@ed.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11132657

Citation

Lee, A J., et al. "Haemostatic Factors and Risk of Varicose Veins and Chronic Venous Insufficiency: Edinburgh Vein Study." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 11, no. 8, 2000, pp. 775-81.
Lee AJ, Lowe GD, Rumley A, et al. Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. Blood Coagul Fibrinolysis. 2000;11(8):775-81.
Lee, A. J., Lowe, G. D., Rumley, A., Ruckley, C. V., & Fowkes, F. G. (2000). Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 11(8), pp. 775-81.
Lee AJ, et al. Haemostatic Factors and Risk of Varicose Veins and Chronic Venous Insufficiency: Edinburgh Vein Study. Blood Coagul Fibrinolysis. 2000;11(8):775-81. PubMed PMID: 11132657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemostatic factors and risk of varicose veins and chronic venous insufficiency: Edinburgh Vein Study. AU - Lee,A J, AU - Lowe,G D, AU - Rumley,A, AU - Ruckley,C V, AU - Fowkes,F G, PY - 2001/1/2/pubmed PY - 2001/4/6/medline PY - 2001/1/2/entrez SP - 775 EP - 81 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 11 IS - 8 N2 - Despite much research, the aetiology of venous disease is still poorly understood. Since haemostatic factors are involved in the processes of fibrinolysis and platelet aggregation, it is conceivable that such processes may be implicated in the pathology of varicose veins and chronic venous insufficiency (CVI). The Edinburgh Vein Study examined 1566 men and women aged 18-64 years that were randomly selected from the lists of 12 general practitioners. Each subject completed a questionnaire, underwent a comprehensive clinical examination and had a blood sample taken for the analysis of plasma fibrinogen, tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) antigens. Subjects with trunk varicose veins and those with CVI had higher levels of each haemostatic factor compared with those with no trunk varices and no CVI. Although unit increases in t-PA and vWF were initially associated with a significantly increased risk of CVI in men, and both factors with an elevated risk of trunk varices in women, multiple adjustment for age, smoking status and body mass index reduced the odds ratios to non-significance. However, this does not entirely rule out the possibility of a pathogenic role for haemostatic factors in venous disease, but rather indicates the need for further experimental and epidemiological studies. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/11132657/full_citation DB - PRIME DP - Unbound Medicine ER -