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Prospective study of dietary fat and the risk of age-related macular degeneration.

Abstract

BACKGROUND

The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear.

OBJECTIVE

Our objective was to examine prospectively the association between fat intake and AMD.

DESIGN

We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged > or = 50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire.

RESULTS

We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and >4 servings of fish/wk was associated with a 35% lower risk of AMD compared with < or = 3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009).

CONCLUSIONS

Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.edu

    , , , , , ,

    Source

    MeSH

    Age Factors
    Aged
    Animals
    Diet Records
    Dietary Fats
    Docosahexaenoic Acids
    Fatty Acids
    Female
    Fishes
    Follow-Up Studies
    Humans
    Macular Degeneration
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    United States
    alpha-Linolenic Acid

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11157315

    Citation

    Cho, E, et al. "Prospective Study of Dietary Fat and the Risk of Age-related Macular Degeneration." The American Journal of Clinical Nutrition, vol. 73, no. 2, 2001, pp. 209-18.
    Cho E, Hung S, Willett WC, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001;73(2):209-18.
    Cho, E., Hung, S., Willett, W. C., Spiegelman, D., Rimm, E. B., Seddon, J. M., ... Hankinson, S. E. (2001). Prospective study of dietary fat and the risk of age-related macular degeneration. The American Journal of Clinical Nutrition, 73(2), pp. 209-18.
    Cho E, et al. Prospective Study of Dietary Fat and the Risk of Age-related Macular Degeneration. Am J Clin Nutr. 2001;73(2):209-18. PubMed PMID: 11157315.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of dietary fat and the risk of age-related macular degeneration. AU - Cho,E, AU - Hung,S, AU - Willett,W C, AU - Spiegelman,D, AU - Rimm,E B, AU - Seddon,J M, AU - Colditz,G A, AU - Hankinson,S E, PY - 2001/2/7/pubmed PY - 2001/3/17/medline PY - 2001/2/7/entrez SP - 209 EP - 18 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 73 IS - 2 N2 - BACKGROUND: The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear. OBJECTIVE: Our objective was to examine prospectively the association between fat intake and AMD. DESIGN: We conducted a prospective follow-up study of participants in the Nurses' Health Study and the Health Professionals Follow-up Study. At baseline (1984 for women and 1986 for men), the study included 42743 women and 29746 men aged > or = 50 y with no diagnosis of AMD who were followed until 1996. Fat intake was assessed with a food-frequency questionnaire. RESULTS: We accrued 567 patients with AMD with a visual loss of 20/30 or worse. The pooled multivariate relative risk (RR) for the highest compared with the lowest quintile of total fat intake was 1.54 (95% CI: 1.17, 2.01; P for trend = 0.008). Linolenic acid was positively associated with risk of AMD (top versus bottom quintile of RR: 1.49; 95% CI: 1.15, 1.94; P for trend = 0.0009). Docosahexaenoic acid had a modest inverse relation with AMD (top versus bottom quintile of RR: 0.70; 95% CI: 0.52, 0.93; P for trend = 0.05), and >4 servings of fish/wk was associated with a 35% lower risk of AMD compared with < or = 3 servings/mo (RR: 0.65; 95% CI: 0.46, 0.91; P for trend = 0.009). CONCLUSIONS: Total fat intake was positively associated with risk of AMD, which may have been due to intakes of individual fatty acids, such as linolenic acid, rather than to total fat intakes per se. A high intake of fish may reduce the risk of AMD. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11157315/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/73.2.209 DB - PRIME DP - Unbound Medicine ER -