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Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)].

Abstract

The propagation pattern of individual pressure waves in the gastroduodenal area in IBS is unexplored. We performed antroduodenojejunal manometry on 26 patients with IBS--13 with diarrhea predominant IBS (IBS-D) and 13 with constipation predominant IBS (IBS-C)--and 32 healthy controls. Neuropathic-like motor abnormalities were found in 38% of the patients with conventional manometric evaluation. With high-resolution analysis additional abnormalities were observed in the majority of the patients, with increased frequency of retrograde pressure waves postprandially in both IBS subgroups and in phase II in IBS-D. A correlation between subjective gastrointestinal symptoms and the frequency of retrograde pressure waves in phase II in IBS-D was demonstrated. Motility indices and the number of long clusters were also higher in patients compared to controls. To conclude, an abnormal propagation pattern of individual duodenal pressure waves in IBS patients was demonstrated and found to be related to symptom severity in diarrhea-predominant IBS. High-resolution analysis adds information to standard manometry.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, and Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Göteborg, Sweden.

    , , ,

    Source

    Digestive diseases and sciences 45:11 2000 Nov pg 2151-61

    MeSH

    Adult
    Colonic Diseases, Functional
    Constipation
    Diarrhea
    Duodenum
    Female
    Gastrointestinal Motility
    Humans
    Male
    Manometry
    Middle Aged
    Reference Values

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11215731

    Citation

    Simrén, M, et al. "Abnormal Propagation Pattern of Duodenal Pressure Waves in the Irritable Bowel Syndrome (IBS) [correction of (IBD)]." Digestive Diseases and Sciences, vol. 45, no. 11, 2000, pp. 2151-61.
    Simrén M, Castedal M, Svedlund J, et al. Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)]. Dig Dis Sci. 2000;45(11):2151-61.
    Simrén, M., Castedal, M., Svedlund, J., Abrahamsson, H., & Björnsson, E. (2000). Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)]. Digestive Diseases and Sciences, 45(11), pp. 2151-61.
    Simrén M, et al. Abnormal Propagation Pattern of Duodenal Pressure Waves in the Irritable Bowel Syndrome (IBS) [correction of (IBD)]. Dig Dis Sci. 2000;45(11):2151-61. PubMed PMID: 11215731.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)]. AU - Simrén,M, AU - Castedal,M, AU - Svedlund,J, AU - Abrahamsson,H, AU - Björnsson,E, PY - 2001/2/24/pubmed PY - 2001/3/7/medline PY - 2001/2/24/entrez SP - 2151 EP - 61 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 45 IS - 11 N2 - The propagation pattern of individual pressure waves in the gastroduodenal area in IBS is unexplored. We performed antroduodenojejunal manometry on 26 patients with IBS--13 with diarrhea predominant IBS (IBS-D) and 13 with constipation predominant IBS (IBS-C)--and 32 healthy controls. Neuropathic-like motor abnormalities were found in 38% of the patients with conventional manometric evaluation. With high-resolution analysis additional abnormalities were observed in the majority of the patients, with increased frequency of retrograde pressure waves postprandially in both IBS subgroups and in phase II in IBS-D. A correlation between subjective gastrointestinal symptoms and the frequency of retrograde pressure waves in phase II in IBS-D was demonstrated. Motility indices and the number of long clusters were also higher in patients compared to controls. To conclude, an abnormal propagation pattern of individual duodenal pressure waves in IBS patients was demonstrated and found to be related to symptom severity in diarrhea-predominant IBS. High-resolution analysis adds information to standard manometry. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/11215731/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11215731.ui DB - PRIME DP - Unbound Medicine ER -