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Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet.

Abstract

The effect of increasing dietary folate on folate status during pregnancy is controversial. The aim of this study was to compare folate intake and folate status during pregnancy of women with high long-term vegetable intake and those eating an average Western diet. In a prospective study that included 109 participants, pregnant women adhering to a predominant vegetarian diet with high vegetable intake for 8 +/- 0.5 y with subgroups of ovo-lacto vegetarians (n = 27) and low meat eaters (n = 43) and women eating an average Western diet (control group, n = 39) were compared with regard to dietary intake and plasma and red blood cell (RBC) folate concentrations during wk 9-12, 20-22 and 36-38 of gestation. Plasma and RBC folate concentrations were highest in ovo-lacto vegetarians, followed by low meat eaters and lowest in the controls. Ovo-lacto vegetarians and low meat eaters showed a lower risk for folate deficiency, with RBC folate concentrations of <320 nmol/L resulting in odds ratios of 0.10 (95% confidence interval, 0.01-0.56) and 0.52 (95% confidence interval, 0.20-1.34), respectively. In ovo-lacto vegetarians, the RBC folate concentration was positively related to the intake of vitamin B-12 (r = 0.51, P: < 0.0001). The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured.

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  • Authors+Show Affiliations

    ,

    Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nuremberg, Waldstrasse 6, D-91054 Erlangen, Germany. Corinna.Koebnick@imbe.imed.uni-erlangen.de

    , , ,

    Source

    The Journal of nutrition 131:3 2001 Mar pg 733-9

    MeSH

    Adult
    Animals
    Diet
    Diet, Vegetarian
    Erythrocytes
    Feeding Behavior
    Female
    Folic Acid
    Folic Acid Deficiency
    Humans
    Meat
    Nutritional Status
    Odds Ratio
    Pregnancy
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Time Factors
    Vegetables
    Vitamin B 12

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    11238752

    Citation

    Koebnick, C, et al. "Folate Status During Pregnancy in Women Is Improved By Long-term High Vegetable Intake Compared With the Average Western Diet." The Journal of Nutrition, vol. 131, no. 3, 2001, pp. 733-9.
    Koebnick C, Heins UA, Hoffmann I, et al. Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet. J Nutr. 2001;131(3):733-9.
    Koebnick, C., Heins, U. A., Hoffmann, I., Dagnelie, P. C., & Leitzmann, C. (2001). Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet. The Journal of Nutrition, 131(3), pp. 733-9.
    Koebnick C, et al. Folate Status During Pregnancy in Women Is Improved By Long-term High Vegetable Intake Compared With the Average Western Diet. J Nutr. 2001;131(3):733-9. PubMed PMID: 11238752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Folate status during pregnancy in women is improved by long-term high vegetable intake compared with the average western diet. AU - Koebnick,C, AU - Heins,U A, AU - Hoffmann,I, AU - Dagnelie,P C, AU - Leitzmann,C, PY - 2001/3/10/pubmed PY - 2001/4/21/medline PY - 2001/3/10/entrez SP - 733 EP - 9 JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 3 N2 - The effect of increasing dietary folate on folate status during pregnancy is controversial. The aim of this study was to compare folate intake and folate status during pregnancy of women with high long-term vegetable intake and those eating an average Western diet. In a prospective study that included 109 participants, pregnant women adhering to a predominant vegetarian diet with high vegetable intake for 8 +/- 0.5 y with subgroups of ovo-lacto vegetarians (n = 27) and low meat eaters (n = 43) and women eating an average Western diet (control group, n = 39) were compared with regard to dietary intake and plasma and red blood cell (RBC) folate concentrations during wk 9-12, 20-22 and 36-38 of gestation. Plasma and RBC folate concentrations were highest in ovo-lacto vegetarians, followed by low meat eaters and lowest in the controls. Ovo-lacto vegetarians and low meat eaters showed a lower risk for folate deficiency, with RBC folate concentrations of <320 nmol/L resulting in odds ratios of 0.10 (95% confidence interval, 0.01-0.56) and 0.52 (95% confidence interval, 0.20-1.34), respectively. In ovo-lacto vegetarians, the RBC folate concentration was positively related to the intake of vitamin B-12 (r = 0.51, P: < 0.0001). The results of the study suggest that long-term high vegetable intake favorably affects plasma folate as well as RBC folate concentrations throughout pregnancy and reduces the risk of folate deficiency if an adequate vitamin B-12 supply is ensured. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11238752/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.3.733 DB - PRIME DP - Unbound Medicine ER -