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Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection.

Abstract

Alcoholic beverages have antimicrobial effects against Helicobacter pylori in vitro. To elucidate the relation between alcohol consumption and current infection with H. pylori in vivo, we carried out a pooled analysis of three recent studies from Southern Germany, comprising 1410 adults age 15 to 69. Detailed information on consumption of various alcoholic beverages was collected through standardized questionnaires. Helicobacter pylori infection was measured by 15C-urea breath test. Overall, prevalence of current H. pylori infection was lower among subjects who consumed alcohol (34.9%) than among nondrinkers (38.0%). The adjusted odds ratio was 0.79, with a 95% confidence interval of 0.58-1.08. Furthermore, alcohol consumption showed a strong inverse relation to the result of the 13C-urea breath test, a semiquantitative measure of the bacterial load, among infected subjects. The inverse association between alcohol consumption and H. pylori infection was not monotonic, however. Odds of infection were lowest at moderate levels of alcohol consumption and increased at higher levels of alcohol consumption, regardless of the type of alcoholic beverages consumed. These results support the hypothesis that moderate alcohol consumption may favor suppression and eventual elimination of H. pylori infection. At higher levels of alcohol consumption, the antimicrobial effects of alcoholic beverages may be opposed by adverse systemic effects of drinking, such as adverse effects on the immune defense.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg.

    , , , ,

    Source

    Epidemiology (Cambridge, Mass.) 12:2 2001 Mar pg 209-14

    MeSH

    Adolescent
    Adult
    Aged
    Alcohol Drinking
    Breath Tests
    Child
    Child, Preschool
    Cross-Sectional Studies
    Disinfectants
    Ethanol
    Female
    Gastritis
    Germany
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Immune System
    Male
    Middle Aged
    Odds Ratio
    Peptic Ulcer
    Prevalence
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11246582

    Citation

    Brenner, H, et al. "Alcohol as a Gastric Disinfectant? the Complex Relationship Between Alcohol Consumption and Current Helicobacter Pylori Infection." Epidemiology (Cambridge, Mass.), vol. 12, no. 2, 2001, pp. 209-14.
    Brenner H, Bode G, Adler G, et al. Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection. Epidemiology. 2001;12(2):209-14.
    Brenner, H., Bode, G., Adler, G., Hoffmeister, A., Koenig, W., & Rothenbacher, D. (2001). Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection. Epidemiology (Cambridge, Mass.), 12(2), pp. 209-14.
    Brenner H, et al. Alcohol as a Gastric Disinfectant? the Complex Relationship Between Alcohol Consumption and Current Helicobacter Pylori Infection. Epidemiology. 2001;12(2):209-14. PubMed PMID: 11246582.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol as a gastric disinfectant? The complex relationship between alcohol consumption and current Helicobacter pylori infection. AU - Brenner,H, AU - Bode,G, AU - Adler,G, AU - Hoffmeister,A, AU - Koenig,W, AU - Rothenbacher,D, PY - 2001/3/15/pubmed PY - 2001/4/21/medline PY - 2001/3/15/entrez SP - 209 EP - 14 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 12 IS - 2 N2 - Alcoholic beverages have antimicrobial effects against Helicobacter pylori in vitro. To elucidate the relation between alcohol consumption and current infection with H. pylori in vivo, we carried out a pooled analysis of three recent studies from Southern Germany, comprising 1410 adults age 15 to 69. Detailed information on consumption of various alcoholic beverages was collected through standardized questionnaires. Helicobacter pylori infection was measured by 15C-urea breath test. Overall, prevalence of current H. pylori infection was lower among subjects who consumed alcohol (34.9%) than among nondrinkers (38.0%). The adjusted odds ratio was 0.79, with a 95% confidence interval of 0.58-1.08. Furthermore, alcohol consumption showed a strong inverse relation to the result of the 13C-urea breath test, a semiquantitative measure of the bacterial load, among infected subjects. The inverse association between alcohol consumption and H. pylori infection was not monotonic, however. Odds of infection were lowest at moderate levels of alcohol consumption and increased at higher levels of alcohol consumption, regardless of the type of alcoholic beverages consumed. These results support the hypothesis that moderate alcohol consumption may favor suppression and eventual elimination of H. pylori infection. At higher levels of alcohol consumption, the antimicrobial effects of alcoholic beverages may be opposed by adverse systemic effects of drinking, such as adverse effects on the immune defense. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/11246582/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=11246582 DB - PRIME DP - Unbound Medicine ER -